| Objective To explore the significance of different types of calcification and related clinicopathological features in the diagnosis of thyroid papillary carcinoma(papillary thyroid carcinoma,PTC).Methods A retrospective study was conducted to sort out all the newly diagnosed cases of thyroid nodules in the first affiliated Hospital of Medical College of Shihezi University from January 1,2019 to December30,2021.Then the cases were collected who met the inclusion and exclusion criteria,including demographic characteristics,elastic ultrasound reports of thyroid nodules,and postoperative pathological results.Ultrasonic calcification was divided into four types of calcification.The relationship between thyroid ultrasonic calcification type and related clinical features and thyroid nodules was explored using the pathological results after thyroid surgery as the gold standard for diagnosis.SPSS24.0 software was used to analyze the data,the measurement data is expressed by ±s,and the counting data is expressed by percentage(%);the measurement data about normal distribution can be analyzed by one-way variance;chi-square test or correlation analysis are adaptable to analyze the measurement data about abnormal distribution,while the counting data can be analyzed by chi-square test.Results 428 patients who meet the criteria were adopted in this study,and 286 patients were included in the final study.428 patients with thyroid nodules were selected in this study.286 patients were included in the final study who met the inclusion and exclusion criteria,including 68 benign thyroid tumors and 218 PTC.Significant difference in gender,BMI,TSH,f T3 and f T4 between benign and malignant thyroid nodules was not found,but the differences in age(≤45 years old,>45 years old),BMI,calcification type and total tumor diameter(total tumor diameter,TTD)between benign and malignant thyroid nodules(P=0.04,0.01,0.00,0.00,respectively)were certificated.TTD was the highest in non-calcified PTC(2.52±2.20)cm,and there was significant difference in TTD among the four groups(P < 0.05).There were significant differences in microcalcification,coarse calcification,mixed calcification and non-calcification(P<0.05).Through Logistic regression analysis,the risk of microcalcification and coarse calcification was increased relative to the occurrence of PTC without calcification(OR=5.58,95%CI 2.91-10.68,P=0.00;OR=2.89,95%CI 1.16-7.24,P=0.02,respectively).The receiver operating characteristic curve(ROC curve)of subjects was drawn for the risk factors of PTC(TTD).The best critical value was 3.65 cm.The sensitivity and specificity of PTC were 0.96 and 0.72.The diagnostic accuracy was moderate.After adjusting the abnormal value in BMI group,Logistic regression analysis showed that the risk of PTC in BMI overweight group was lower than that in BMI normal group(OR=0.34,95%CI 0.14-0.82),but there was no significant difference between BMI obesity group and normal group(P > 0.05).Conclusion 1.Different types of calcification are closely related to the occurrence of papillray thyroid carcinoma.in addition to microcalcification,coarse calcification should also be paid more attention to in the diagnosis of thyroid cancer.2.At the same time,attention should be paid to the clinical significance of the total diameter of multifocal tumors,which can more comprehensively reflect the invasive significance of multifocal tumors.3.Overweight relative to normal BMI is not a risk factor for PTC. |
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