| Objectives To investigate the association of preoperative serum TSH and microcalcifications within reference ranges with the aggressiveness of papillary thyroid carcinoma.Methods Patients who were diagnosed with papillary thyroid carcinoma by postoperative pathological diagnosis from September 2018 to June 2021 in the Glandular Surgery Department of Hebei General Hospital were selected as the research subjects,and560 patients who met the inclusion and exclusion criteria were enrolled.Among them,329patients were papillary thyroid carcinoma patients with intranodular microcalcifications,and 231 patients were papillary thyroid carcinoma patients without microcalcifications.The gender,age,history of thyroid disease,preoperative serum TSH value,preoperative thyroid ultrasonography,and postoperative pathological results of the 560 patients were collected.SPSS 25.0 statistical software package was used to conduct statistical analysis on the collected data.First,χ~2 test,rank sum test,t test,etc.were used for univariate analysis.Finally,the correlation between TSH and microcalcifications and the aggressiveness of papillary thyroid cancer was obtained.Results 1 The enrolled patients with papillary thyroid carcinoma were divided into two groups according to the presence or absence of cervical lymph nodes,including 217patients in the PTC group with lymph node metastasis and 343 patients in the PTC group without lymph node metastasis.Univariate analysis showed that there were significant differences in TSH(P=0.048)and microcalcification(P<0.001)between groups.Multivariate analysis showed that microcalcification was positively correlated with cervical lymph node metastasis(P<0.001),while TSH had no correlation with cervical lymph node metastasis.2 The patients with papillary thyroid carcinoma were divided into two groups according to the presence or absence of microcalcification.There were 329cases in the group with microcalcification and 231 cases in the group without microcalcification.There were significant differences in maximum diameter(P=0.002),cervical lymph node metastasis(P<0.001),and multifocality(P=0.036).There was no significant difference in TSH between the two groups(P=0.801).Multivariate analysis showed that tumor diameter(P<0.001)and CLNM(P=0.001)were positively correlated with microcalcification in papillary thyroid carcinoma.3 The patients with papillary thyroid carcinoma were divided into two groups according to different factors,and the differences of TSH in each group were compared.Univariate analysis showed that the tumor diameters were divided into two groups according to whether the tumor diameter was less than or equal to 1.0cm,and the TSH between the two groups(P=0.034).The difference was statistically significant;gender(P=0.012),the nodular goiter group(P=0.001),the Hashimoto’s thyroiditis group(P=0.033),the TSH differences were all statistically significant.There was no significant difference in TSH values between the two groups in terms of whether there was lymph node metastasis in the lateral neck region,whether there was extra-glandular invasion,and whether there was multifocality between the two groups(P>0.05).Multivariate analysis showed that:gender(P=0.009),nodular goiter(P=0.007)were associated with TSH level,while tumor diameter,cervical lymph node metastasis,and Hashimoto’s thyroiditis were not associated with TSH level Correlation.Conclusions 1 Papillary thyroid carcinoma with intranodular microcalcification is more aggressive,manifested as a higher rate of cervical lymph node metastasis,larger tumor diameter,and cervical lymph nodes should be removed during surgery,while TSH elevated within the reference range.Does not increase the aggressiveness of papillary thyroid carcinoma.2.Gender,nodular goiter affect TSH levels within the reference range.3Microcalcifications are not associated with elevated serum TSH levels within the reference range.Figure0;Table7;Reference132... |
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