Effect Of Metabolic Syndrome And Components On The Stage And Grading Of Bladder Cancer

Objective:1.To study and explore the effects of metabolic syndrome and various components on the stage and classification of bladder cancer.2.Compare whether there are differences in metabolism-related factors between bladder cancer patients and physical examination populations.Methods:310 cases of pathologically confirmed primary bladder urothelial carcinoma were collected from June 2017 to June 2020 in the Urology Department of Qing Hai Affiliated Hospital,and the relevant metabolic indicators of bladder cancer patients were retrospectively analyzed,and according to whether there was metabolic syndrome,they were divided into simple bladder cancer group and bladder cancer comorbid metabolic syndrome group.The correlation between the stages and grades of bladder cancer and the components of metabolic syndrome and the stages and grades of bladder cancer were analyzed.Using case-control research methods,age,sex,height,weight,BMI,past history,blood glucose and blood lipids were collected,TNM staging adopted the 8th edition of TNM staging released by the International Cancer Alliance in 2017,Ta and T1 were regarded as low staging,T2,T3 and T4 were considered high staging,tissue grading was graded by 2004 grading,and low-grade malignant potential papillary urothelial tumors were considered low-grade.The chi-square test was used to analyze the metabolic syndrome and the correlation between various elements and the staging and grading of bladder cancer,including four aspects: hypertension,blood,glucose abnormalities,obesity and dyslipidemia.At the same time,the population who were examined in the physical examination center of the Affiliated Hospital of Qinghai University in the same period was randomly selected to compare whether there were differences in metabolism-related factors between bladder cancer patients and the physical examination population.Results:1.General data of the two groups: A total of 310 cases of bladder cancer were collected,including 248 cases of males and 62 cases of females,the male to female ratio was 4:1,with an average age of(62.70±11.20)years.Patients were divided into bladder cancer with metabolic syndrome group and bladder cancer alone group according to whether they had metabolic syndrome.There were 87 patients(61.61±10.77)in the bladder cancer group with metabolic syndrome,and 223 patients(63.13±11.36)in the bladder cancer group with metabolic syndrome.High TNM stage and low TNM stage were 52.9% and 47.1%,respectively.Histological grading was 60.9% for high grade and 39.1% for low grade.According to our data,the chi-square analysis showed that the TNM stage(P=0.004)and tumor histological grade(P=0.001)of patients with bladder cancer co-metabolic syndrome were higher than those of patients with bladder cancer alone,and the difference was statistically significant.2.The correlation between the components of metabolic syndrome and the TNM stage and histological classification of bladder cancer: hypertension,TG abnormalities,and HDL-c abnormalities were not statistically significant in the TNM staging and histological classification of bladder cancer.Abnormal BMI and blood glucose abnormalities are of statistical significance in TNM staging and histological grading of bladder cancer.3.Comparison of bladder cancer patients with the blank control group: 310 patients with bladder cancer,248 males and 62 females,with an average age(62.70±11.20)years were collected.In the blank control group,there were 271 patients,206 males and 65 females,with an average age of(46.09±15.40).The basic characteristics of the bladder cancer group and the blank group showed no statistical significance for male and female,which was comparable.4.Univariate analysis of bladder cancer patients and blank control group showed that there were no statistically significant differences in abnormal TG,abnormal HDL-c and hypertension between the two groups,while there were statistically significant differences in abnormal blood glucose and abnormal BMI.Conclusion: 1.The clinical TNM stage and histological grade of the bladder cancer group with metabolic syndrome were significantly higher than that of the bladder cancer group alone.In this retrospective analysis,abnormal BMI and abnormal blood glucose were also found to have higher TNM stage and histologicalgrade in bladder cancer patients.2.The incidence of bladder cancer may be related to metabolic factors,and diabetes and obesity may increase the risk of bladder cancer.