Meta-analysis Of The Relationship Between Metabolic Syndrome And Hepatobiliary Malignancy Disease Risk

Background:Metabolic syndrome is a common disease worldwide.The prevalence of metabolic syndrome varies between 24% and 46%,with a higher prevalence in western countries.Recently,the incidence of metabolic syndrome in developing country is also increased.The prevalence of metabolic syndrome approximately varies from 8% to 20% in China.Metabolic syndrome has become a major disease which is threatening to human’s health.Nowadays,the diagnostic standard about metabolic syndrome is not unified in the world.At present,WHO and NCEP-ATP Ⅲis the common diagnostic standard for metabolic syndrome.But there is a big difference between Chinese people and foreigners,we have already formulated new diagnostic standard for Chinese people in 2007.Although the three metabolic syndrome diagnostic criteria are not entirely consist,but we can clear sure that metabolic syndrome is an assemblage of metabolic abnormalities including body mass index or central obesity,diabetes,insulin resistance,dyslipidemia,and elevated blood pressure.It is well known that subjects with MS are at significant risk of cardiovascular diseases.Recently,it has been reported that the metabolic syndrome is closely related to the occurrence of multiple tumors,such as breast cancer,colorectal cancer,prostate cancer and so on.There is a large controversial about the effect of metabolic syndrome on the occurrence of hepatobiliary malignance disease.There are some studies reported that metabolic syndrome can induce the occurrence of hepatobiliary malignance disease.But others didn’t show any relation between metabolic syndrome and hepatobiliary malignancy disease.Up to now,there is still not any evidence-based basis at home and abroad about the relationship between metabolic syndrome and the hepatobiliary malignance disease.This research intends to adopt the methods of the Cochrane system evaluation to provide evidence for the prevention and treatment the hepatobiliary malignancy disease.To evaluate the relationship between metabolic syndrome and hepatobiliary malignancy disease by Cochrane Meta-analysis,in order to find efficacy strategy to prevent and treat the hepatobiliary malignancy disease.Methods:We searched the PubMed,EMBASE,VIP,Wanfang Data,CBM,CNKI to collect literature which discuss the relationship between metabolic syndrome and hepatobiliary malignancy disease.The Primary outcome is the risk of hepatobiliary malignancy disease at the metabolic syndrome exposure by Cochrane collaboration Stata11.0 software.Results:After retrieving all the databases,8 studies involving 5 cohort studies and 3 case-control studies with a total of 1428036 people were included.The results of meta-analysis showed that,metabolic syndrome had a higher incidence rate in hepatobiliary malignancy disease(RR=1.71,95%CI:1.42~2.06,P<0.05);According to the gender difference,we divided the included studies into two subgroups,we found there has a higher risk of hepatobiiary malignancy disease in male(RR=1.55,95%CI:1.21-1.99,P<0.05),but in female,this association was not found(RR=1.48,95%CI:0.73~3.01,P=0.282).Subgroup analysis showed metabolic syndrome had a higher risk of hepatobiliary malignancy disease in Asia people and European and American people,RR=2.13,95%CI:1.53-2.95,P<0.05 and RR=1.55,95%CI:1.24-1.95,P<0.05.Based on different design types,we divided the included studies into two subgroups.We found that relationship between metabolic syndrome and hepatobiliary malignancy was not changed both in case-control studies(RR=2.07,95%CI:1.60-2.70,P<0.05)and cohort studies(RR=1.41,95%CI:1.25-1.58,P<0.05).Sensitivity analysis showed that the positive association between metabolic syndrome and hepatobiliary malignancy was not changed after excluding case-control studies,suggested the results were stable.Begg’s text and Egger’s text indicated little evidence of publication bias(P>0.05).ConclusionThe research results show that metabolic syndrome is a risk factor of the hepatobiliary malignancy disease does not exist regional differences,however,it exist gender differences.It founds that metabolic syndrome is a risk factor of inducing hepatoboliary malignancy in Objective: male,not found association in female.