The Correlation Studies Of Metabolic Syndrome And Prostate Cancer

Objective:Observe and analyse the incidence of metabolic syndrome in Han nationality variance between people with prostate cancer and normal physical examination, people with prostate cancer and prostatic hyperplasia, analyse the relativity between metabolic syndrome with its component and prostate cancer.Methods: 211 prostate cancer patients age range from 50 - 90 in the Union Hospital of Fujian Medical University were chosed between September 2003 and September 2009 in Fujian Medical University Union Hospital, and according to PSA value we divide them into three sub-groups, the low group (PSA<10ng/ml), the middle group(PSA 10—20ng/ml) and the high group (PSA>20ng/ml). 215 normal physical examination people and 215 newly diagnosis of prostatic hyperplasia patients were chosed randomly as the other two control groups. Fasting venous blood in the morning were tested with certain measures in all the objects, and BMI and blood pressure were test at the same time, finally we perform the statistical analysis.Results: Compare to the prostate cancer group and the prostatic hyperplasia group, there were no statistical sense in BMI, blood pressure, blood glucose, HDL-C, triglyceride, total cholesterol and LDL-C. But the variance except blood pressure between the prostate cancer group and the normal group had statistical significance. The univariate and multivariate non-conditional logistic regression model analysis showed that there had a negative correlation between metabolic syndrome and the incidence of prostate cancer.(OR=0.594;95%CI:0.368,0.960),the same between the amount of the metabolic syndrome group and the incidence of prostate cancer(OR=0.828; 95%CI:0.701,0.978),but there had a positive correlation between metabolic syndrome and the PSA level of the prostate cancer patients(OR=2.255; 95%CI: 1.123,4.527).Blood glucose and HDL-C level had a positive correlation with prostate cance(rOR=6.318; 95%CI: 4.035,9.892,OR=5.898; 95%CI: 2.593, 13.415), and triglyceride had a negative correlation with prostate cancer ( OR=0.521; 95%CI:0.320,0.850). Conclusion: The metabolic level (BMI, blood pressure, blood glucose, HDL-C, triglyceride, total cholesterol and LDL-C) of the prostate cancer patients was similar with the prostatic hyperplasia patients, but there was significant variance (except blood pressure) when it compared with healthy people.Metabolic syndrome may be a protective factor of prostate cancer, and with the amount of metabolic syndrome component growing, there is less risk of prostate cancer.High blood glucose and low HDL-C may be the risk factors for prostate cancer, but high triglyceride may be the protective factor, and BMI and blood pressure have no obviously relationship with prostate cancer.