Clinical Study Of Xinshuikang Capsule In Treating Chronic Heart Failure Of Coronary Heart Disease With Yang Deficiency And Water Accumulation

Objective:On the basis of the standardized treatment of western medicine,combined with Xinshuikang capsule in the treatment of chronic heart failure of coronary heart disease caused by yang deficiency and water accumulation,the cardiac function classification,LVEF,NT-proBNP,TCM syndrome score and other indicators of the patients we reobserved,and the clinical efficacy and safety of Xinshuikang capsule was analyzed.To provide a basis for clinical treatment of coronary heart disease and chronic heart failure.Methods:A total of 60 patients with chronic heart failure with coronary heart disease and TCM syndrome differentiation of yang deficiency and water accumulation from December 2020 to November 2021 in the outpatient and inpatient departments of the Department of Cardiology,Inner Mongolia Autonomous Region Hospital Of Traditional Chinese Medicine were randomly divided into the control group and the treatment group,with 30 patients in each group.Both groups were given conventional western medicine treatment,and the treatment group was given Xinshuikang capsule(Provided by the Preparation Center of the Inner Mongolia Autonomous Region Hospital Of Traditional Chinese Medicine),on the basis of conventional western medicine treatment for 8 weeks.Cardiac function grading,TCM syndrome score,Lee’s heart failure score,6MWD,MLHFQ score,LVEF,NT-proBNP before and after treatment in the two groups were observed,and safety indicators such as blood and urine routine,liver and kidney function were evaluated.Results:(1)After 8 weeks of treatment,the levels of ejection fraction in the two groups were improved compared with before,the ejection fraction in the treatment group was 47.10±2.35%,and the ejection fraction in the control group was 44.35±2.60%.The level of ejection fraction in the treatment group was significantly improved compared with the control group.Statistical significance(P<0.05).(2)After 8 weeks of treatment,the NT-proBNP in the treatment group was 1529.13±482.99pg/ml,and the NT-proBNP in the control group was 1837.72±643.53pg/ml.The levels of NT-proBNP in the treatment group and the control group were improved compared with before,and the treatment group was lower than the control group.The degree was obvious,and the difference was statistically significant(P<0.05).(3)After 8 weeks of treatment,all subjects performed a 6-minute walking distance test to evaluate the patients’ exercise tolerance.The walking distance in the treatment group was 385.60±37.37m,and the walking distance in the control group was 345.93±25.83m.The walking distance in the treatment group increased significantly,and the difference was significant.Statistically significant(P<0.05).(4)After the subjects were treated for 8 weeks,the symptoms of TCM were improved in both groups.The efficacy of TCM syndromes in the treatment group was 90.0%,and the efficacy of TCM syndromes in the control group was 69.0%,and the difference was statistically significant(P<0.05).(5)After 8 weeks of treatment,the scores of the Minnesota Quality of Life Scale in both the treatment group and the control group decreased,the MLHFQ score in the treatment group was 35.33±4.31,and the MLHFQ score in the control group decreased by 44.76±5.17,and the decrease in the treatment group was significant,and the difference was statistically significant(P<0.05).(6)After 8 weeks of treatment,the cardiac function of the treatment group and the control group were improved,and the cardiac function efficacy of the treatment group and the control group were 86.7%and 69.0%,respectively,and the difference was statistically significant(P<0.05).Conclusion:On the basis of conventional western medicine treatment,Xinshuikang capsule can effectively relieve the clinical symptoms of coronary heart disease and heart failure(yang deficiency and water accumulation)patients,improve cardiac function,reduce the level of NT-proBNP,increase the level of left ventricular ejection fraction and Exercise tolerance,Xinshuikang capsule have few side effects,and the clinical medication safety is high.