Correlation Between Meteorological Factors And The Risk Of Acute Cerebral Infarction And Its Subtypes

Objective To explore the correlation between the changes of daily meteorological factors and the daily incidence of acute cerebral infarction and its etiological classification.To analyze the main meteorological factors affecting the incidence of acute cerebral infarction.Methods Data of all hospitalized patients with first-onset acute cerebral infarction who met the inclusion criteria and were admitted to the Department of Neurology of Baotou Central Hospital from November 1,2020 to October 31,2021 were continuously collected.And the subtypes were classified according to TOAST(Trial of Org 10172 in Acute Stroke Treatment)etiological classification standard.The meteorological data of the same period were provided by Baotou Meteorological Bureau,including daily average temperature(℃),daily maximum temperature(℃),daily minimum temperature(℃),daily average pressure(h Pa),daily maximum pressure(h Pa),daily minimum pressure(h Pa),daily average relative humidity(%),sunshine hours(h),daily average wind speed of 2 minutes(m/s),daily maximum wind speed(m/s),daily temperature difference(℃),etc.The relationship between the number of patients of acute cerebral infarction and its subtypes and meteorological factors was explored by linear correlation analysis and multivariate stepwise regression analysis,respectively.Results During the study period,there were 1260 patients with acute cerebral infarction who met the inclusion criteria,including 600 cases of large artery atherosclerosis(LAA),72 cases of cardiac embolism(CE),506 cases of small artery occlusion(SAA),and 82 cases of other definite etiology and unknown etiology.The ratio of male to female was 1.72:1,with 757 males(62.9%)and 447females(37.1%),with an average age of 64.54 ± 11.39.The univariate correlation analysis between acute cerebral infarction and meteorological factors showed that the daily incidence of acute cerebral infarction was significantly positively correlated with daily mean air temperature,daily maximum air temperature,sunshine duration and daily temperature range(r =0.113,P < 0.05;r = 0.136,P <0.01;r = 0.118,P < 0.05;r =0.152,P < 0.01),and was negatively correlated with daily mean,daily maximum and daily minimum atmospheric pressure(r=-0.129,P< 0.05;r = 0.127,P < 0.05;r = 0.120,P < 0.05);The number of patients with CE was significantly negatively correlated with daily average temperature and daily maximum temperature(r =-0.114,P < 0.05).r =-0.119,P < 0.05);The daily number of SAA was significantly positively correlated with daily mean temperature,daily maximum temperature,and daily temperature range(r=0.110,P < 0.05;r = 0.138,P < 0.01;r =0.157,P < 0.01),and was negatively correlated with daily mean,daily maximum and daily minimum pressure(r=-0.161,P < 0.01;r = 0.158,P < 0.01;r = 0.157,P < 0.01).In multiple stepwise regression analysis,the meteorological factors leading to acute cerebral infarction mainly included daily mean temperature and daily temperature range,The dependent variable is judged by standardized partial regression coefficient,and the order of influence is: daily range of temperature and daily average temperature,(P< 0.05);Meteorological factors affecting LAA include daily mean temperature,daily maximum temperature and daily temperature difference,and the order of influence was determined by the standardized partial regression coefficient as the dependent variables: daily mean temperature,daily maximum temperature and daily temperature range(P< 0.05).The meteorological factors causing CE mainly included daily mean temperature(P< 0.05).Etiological subtypes should be consider when studyiedng the relationship between meteorological factors and the incidence of acute cerebral infarction.Meteorological factors leading to SAA mainly included daily mean2-minute wind speed and daily minimum atmospheric pressure(P < 0.05).The order of influence was determined by using standardized partial regression coefficient as the dependent variable: daily minimum atmospheric pressure and daily mean 2-minute wind speed.Conclusion 1.High temperature and large range of daily temperature change may affect the onset of acute cerebral infarction.2.The effect of meteorological factors on the risk of acute cerebral infarction varies according to the TOAST classification of cerebral infarction.