Observation Of Curative Effect Of Lianchen Decoction On Obesity And Its Effect On Serum IL-6、IL-10、GLP-1 And PYY

Objective: To observe the clinical efficacy and safety of Lianchen Decoction in the treatment of obese patients(spleen deficiency and dampness type),and to provide a clinical basis for the treatment of obesity with traditional Chinese medicine.Possible mechanisms of decoction in the treatment of obesity.Methods: Sixty patients who met the inclusion criteria were randomly divided into control group(n=30)and treatment group(n=30).The control group was given lifestyle intervention(diet and exercise control),and the treatment group was given Lianchen Decoction 150 ml,twice a day,for 12 weeks.The changes of TCM symptom scores,body weight,BMI,WHR,blood lipids,IL-6,IL-10,GLP-1,and PYY of the two groups of patients before and after treatment were compared,and analyzed by SPSS25.0 software.Results:1.A total of 60 patients were included in this study,and 1 case dropped out in the treatment group,with a total dropout rate of 1.66%.2.Comparison of the total effective rate of Chinese medicine: the total effective rate of the control group was 56.66%,and the total effective rate of the treatment group was 82.76%,the curative effect was significantly better than that of the control group(P<0.01).3.Comparison of TCM syndrome scores: after treatment,the syndrome scores of the two groups decreased(P<0.01),loose stools and other aspects were better than the control group(P<0.05).4.Comparison of body weight,BMI and WHR: After treatment,body weight and BMI of the two groups decreased(P<0.05);the WHR of the treatment group decreased significantly after treatment(P<0.05),and there was no significant difference in the observation group.5.Blood lipids: After treatment,blood lipid levels in both groups decreased(P<0.05),and the decreased levels of TC TG and LDL-C in the treatment group were better than those in the control group(P<0.05).6.Intestinal peptide hormones: After treatment,the levels of GLP-1 and PYY in the two groups increased,and the increase in the treatment group was better than that in the control group(P<0.05).7.IL-6,IL-10: After treatment,the levels of IL-6 in both groups decreased,and the decreased level in the treatment group was better than that in the control group(P<0.05);the level of IL-10 in the treatment group increased significantly after treatment,and there was no significant difference in the control group.The improvement of IL-10 level in the treatment group was better than that in the control group(P<0.01).8.Safety analysis: There were no adverse reactions in the two groups after treatment,the liver and kidney functions were normal,and the safety was good.Conclusion:1.Lianchen Decoction can improve the clinical symptoms of obese patients with spleen deficiency and dampness sleepiness,reduce the patient’s TCM syndrome scores,and reduce the levels of body weight,BMI,and WHR.2.Lianchen Tang can reduce blood lipids and regulate lipid metabolism disorders.3.Lianchen Decoction can increase the level of IL-10,reduce the level of IL-6,regulate the disturbance of inflammatory factors;and can improve the levels of GLP-1 and PYY;To sum up,it shows that Lianchen Decoction has a certain therapeutic effect on obese patients with spleen deficiency and dampness.