| Objective By observing the improvement of clinical symptoms and efficacy indicators of 51 patients with PCM in mass stage who met the inclusion criteria,the clinical efficacy and safety of self-made empirical ointment Ruyong ointment were evaluated,so as to provide a research basis for more effective treatment of PCM in mass stage.Methods From January 2021 to December 2021,5 1 patients with PCM who met the inclusion criteria were selected from the outpatient department of the second Department of surgery of the First Affiliated Hospital of Heilongjiang University of traditional Chinese medicine.According to the random number table method,they were divided into three groups:control group A,control group B and observation group.Control group A was given Chaihuqinggan Decoction orally.Control group B and observation group were externally applied with Ruyijinhuang Powder and Ruyong ointment respectively on the basis of control group A.Three weeks after treatment,the symptoms of breast pain,breast redness,breast lump,nipple discharge and nipple depression in the three groups were scored,and the mass volume before and after treatment was recorded.The symptom score and volume reduction rate before and after treatment were compared,and the efficacy evaluation results were analyzed,and the relevant data were statistically discussed and summarized.Results 1.Difference in volume reduction:After treatment,the mass volume of patients in the three groups was reduced to a certain extent(P<0.05),among which control group B and observation group had more obvious effect(P<0.01);Pairwise comparison of tumor reduction volume among the three groups showed significant difference between control group A and control group B and between observation group(P<0.05),but no statistical difference between control group B and observation group(P>0.05).2.Evaluation of TCM syndrome score:after treatment,there was no significant change in nipple depression score among the three groups(P>0.05);The scores and total scores of other TCM symptoms were lower than those before treatment(P<0.05).There were significant differences between control group A,control group B and observation group(P<0.05)in the treatment effect of breast lump,breast redness score and total score among the three groups,while there was no significant difference between control group B and observation group(P>0.05).There was statistical difference in breast pain score between the two groups(P<0.05),and observation group B was superior to control group A.There were no significant differences in nipple depression and nipple discharge scores between the two groups(P>0.05).3.Clinical efficacy evaluation:according to the observation of the curative effect of mass volume reduction rate,the curative effect of control group B and observation group was better than that of control group A in volume reduction rate(P<0.05),but there was no curative effect difference between control group B and observation group(P>0.05).According to the curative effect observation of TCM syndrome score,the three groups were compared in pairs.The comparison of TCM syndrome score between control group B and observation group was better than that of control group A(P<0.05),but there was no curative effect difference between control group B and observation group(P>0.05).4.Recurrence:Follow-up three months later,the recurrence rates of control group A,control group B and observation group were 20.00%,13.3 3%and 13.3 3%,respectively,with no statistical significance.(P>0.05).Conclusion1.On the basis of oral administration of Chaihuqinggan Decoction,external application of Ruyong ointment or Ruyijinhuang powder has significant effect and good safety in the treatment of PCM in the stage of liver meridian heat accumulation mass.2.There is no significant difference between Ruyong ointment and Ruyijinhuang powder in the treatment of PCM in liver meridian heat accumulation mass stage,but Ruyong ointment is better than Ruyi jinhuang powder in analgesic effect. |
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