Clinical Study On The Efficacy Of Mirabegron In The Treatment Of Overactive Bladder After Transurethral Resection Of The Prostate

Objective:To explore the clinical efficacy of mirabegron in the treatment of overactive bladder after transurethral resection of the prostate（TURP）.Methods:A total of 90 patients who underwent TURP in our hospital from February 2020 to January 2021 were selected and randomly divided into mirabegron group（mirabegron 50mg,qd）,solifenacin group（solifenacin 5 mg,qd）,control group（blank control）,and each group has 30 cases.The postoperative bladder spasm pain frequency and duration of bladder spasm in each group three days after TURP,the frequency of urination,urgency,and nocturia on 1st day after catheter removal,the maximum urine flow rate(Q_max),postvoid residual（PVR）,OABSS and QOL score before TURP and one month after TURP were recorded.Results:The number of bladder spasm pain frequency and duration of bladder spasm three days after TURP in the experimental group were less than those in the control（P<0.05）.The number of bladder spasm pain frequency three days after TURP in the mirabegron group were（0.63±0.49）times,（1.67±0.48）times,（1.53±0.51）times,compared with（0.67±0.48）times,（1.73±0.45）times,（1.47±0.51）times in the solifenacin group,the difference was not statistically significant（P>0.05）.The duration of bladder spasm three days after TURP in the mirabegron group were（0.82±0.54）h,（1.04±0.43）h,（0.78±0.37）h,compared with the solifenacin group（0.78±0.48）h,（1.11±0.31）h and（0.81±0.29）h,the difference was not statistically significant（P>0.05）.The frequency of urina-tion,urgency,and nocturia in the test group on 1st day after catheter removal were less than those in the control group（P<0.05）.The frequency of urination,urgency,and noc-turia in the mirabegron group were（9.33±2.97）times,（5.87±2.62）times,and（1.27±0.45）times,compared with the solifenacin group（9.60±3.12）times,（6.17±2.98）times,and（1.23±0.43）times,the difference was not statistically significant（P>0.05）.There was no statistically significant difference in the preoperative Q_maxor PVR among three groups（P>0.05）.Q_max and PVR in the mirabegron group were（21.17±6.18）m L/s,（37.37±16.78）m L,compared with the control group（20.40±6.47）m L/s,（34.30±17.18）m L,the difference was not statistically significant（P>0.05）.Q_max and PVR in the solifenacin group were（10.83±6.98）m L/s and（59.77±16.14）m L,respectively com-pared with the mirabegron group and the control group,the difference was statistically significant（P<0.05）.The preoperative OABSS and QOL comparisons was not statisti-cally significant among three groups（P>0.05）.The OABSS and QOL scores of mira-begron group after one month of TURP were（5.33±1.71）points and（2.30±1.18）points,compared with the solifenacin group（5.30±2.14）points and（2.30±1.09）points,the difference was not statistically significant（P>0.05）,respectively.Compared with the control group（7.53±1.98）points,（3.10±1.21）points the difference was statistically significant（P<0.05）.Conclusion:1.Mirabegron and solifenacin were both effective in the treatment of overactive bladder after TURP.2.Mirabegron did not affect the changes of Q_maxand PVR after TURP,which was conducive to postoperative rehabilitation of patients,with higher safety.3.Mirabegron is recommended for the treatment of overactive bladder after TURP.