Clinical Observation Of Chaihulonggumulitang In Treating Hypertension With Shaoyang Syndrome Combined With Anxiety State

Objective:To provide clinical reference for the prevention and treatment of essential hypertension with anxiety,the clinical effect of Chaihulonggumulitang on shaoyang syndrome of essential hypertension with anxiety was observed.Methods:Patients with shaoyang syndrome essential hypertension with anxiety state meeting the inclusion criteria from January 2021 to December 2021 were randomly divided into control group and experimental group,32 patients in each group were treated with cognitive behavioral therapy and amlodipine besylate tablets.The experimental group was additionally treated with Chaihulonggumulitang on the basis of the control group,and the treatment cycle was 8 weeks.The clinical blood pressure,TCM syndrome score,self-rating anxiety scale,hamilton anxiety scale and heart rate variability were compared between 2 groups before and after treatment.Results:1.Basic information: A total of 64 cases were included in this study,a total of 30 cases were completed,1 case was dropped and 1 case was excluded from the experimental group.The control group fell off 2 cases.A total of 60 cases were completed in this study,and the shedding rate was 6.25%.2.Consulting room blood pressure: there was statistically significant difference in consulting room blood pressure between the two groups before and after treatment(P<0.05);After treatment,there was statistical difference in blood pressure between groups(P<0.05).The total effective rate was 90% in the test group and 73.3% in the control group,with statistical significance(P<0.05).3.TCM syndrome score: there was statistically significant difference between the two groups in TCM syndrome score before and after treatment(P<0.05);There was statistically significant difference in TCM syndrome score between groups after treatment(P<0.05).The total effective rate of TCM syndromes in the observation group was 90% and that in the control group was 70%,the difference was statistically significant(P<0.05).4.Anxiety state scores(SAS,HAMA): anxiety state scores(SAS,HAMA)before and after treatment in 2 groups were statistically significant(P<0.05);There were statistically significant differences in anxiety state scores(SAS,HAMA)between groups after treatment(P<0.05).5.Heart rate variability : There was no significant difference in ratio between low frequency and high frequency before and after treatment in the control group(P>0.05).The differences were statistically significant(P<0.05).There were no statistically significant differences in low frequency and the ratio between low frequency and high frequency between2 groups after treatmen(P>0.05),while there were statistically significant differences in other HRV indexes between 2 groups after treatment(P<0.05).6.Safety indicators: There were no significant changes in blood routine,urine routine,stool routine,liver function,kidney function and routine electrocardiogram before and after treatment in experimental group and control group.Conclusion:Chaihulonggumulitang combined with conventional therapy for essential hypertension with anxiety can effectively improve the clinic blood pressure,TCM syndromes,anxiety symptoms and heart rate variability related indicators of patients.There were no obvious adverse reactions during observation.It is worthy of further clinical research and application.