Correlation Between Cognitive Impairment And Anxiety And Depression In Patients With Essential Hypertension

Objective: To explore the correlation between cognitive dysfunction and anxiety and depression in patients with essential hypertension by testing the scores of Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA)and mini mental state examination(MMSE).Methods: This is a prospective control study.172 patients with essential hypertension were enrolled in our hospital from August 2019 to February2020.According to the results of Mini Mental State Examination(MMSE),the patients were divided into normal cognitive function group(n = 78,MMSE score ≥ 27)and cognitive dysfunction group(n = 94,MMSE score< 27).General data of the two groups were collected,and blood routine,serum creatinine,cholesterol,fasting blood glucose,high sensitivity C-reactive protein and other parameters were detected.Pearson correlation analysis was used to explore the correlation between MMSE score and HAMD score,HAMA score and other indicators.Binary logistic regression analysis was used to explore the risk factors of cognitive impairment in patients with essential hypertension,and ROC curve analysis was used to explore the predictive effect of HAMD score on cognitive impairment in patients with essential hypertension.Results:(1)Compared with normal cognitive function group,patients in cognitive impairment group had higher age,less education years,lower MMSE and MOCA scores,and higher HAMA and HAMD scores(P<0.05).(2)Age(r=-0.38,P<0.01),HAMA score(r=-0.40,P< 0.01),HAMD score(r=-0.49,P<0.01)and course of hypertension(r=-0.17,P<0.05)were negatively correlated with MMSE score,while years of Education(r=0.53,P<0.01)were positively correlated with MMSE score.(3)Age,years of education and depression were independent risk factors for cognitive dysfunction in patients with essential hypertension.(4)HAMD score can predict the occurrence of cognitive impairment in patients with essential hypertension.AUC value is 0.710.When the cut-off value is 9.5,the sensitivity is 77.7%,and the specificity is 65.4%.Conclusions: Age,years of education and depression are independent risk factors for cognitive impairment.HAMD score can predict the occurrence of cognitive impairment in patients with essential hypertension,but HAMA score is not an independent risk factor for the degree of cognitive impairment.