| Objective:To investigates the clinical efficacy of kanlisha acupuncture patching double neiguan and Shenque acupuncture in preventing breast cancer chemotherapy-related nausea and vomiting.Methods:From March 2019 to March 2020,the breast department of a tertiary Chinese medicine hospital in Guangdong Province,108 breast cancer patients who met the inclusion exclusion criteria and received anthracycline plus cyclophosphamide chemotherapy for the first time were screened and divided into experimental groups(n=54)and control groups(n=54)in order of hospitalization.The control group was treated with routine anti-vomiting therapy and dietary guidance;on this basis,acupressure was applied to the experimental group.The incidence and severity of nausea and vomiting,as well as the effects of acute and delayed nausea and vomiting,were compared between the two groups of chemotherapy for 24 h to 7 d.SPSS 23.0 was used to establish the database,and double double loss was used for data entry,proofreading and correction to ensure data completeness and accuracy.For the measurement data in the observation data,all normality tests were used.Two groups were compared with t-test or corrected t-test data,and the count data were described by the number of cases and rates,and theχ~2test or correctedχ~2test were used for the comparison of the incidence and severity of reactions such as vomiting and nausea in the two groups.Statistical extrapolation test levelα=0.05.Results:(1)The age(t=0.704,P=0.483),BMI index(t=0.511,P=0.611),BMI classification(χ~2=0.192,P=0.979),previous pregnancy reaction(χ~2=0.787,P=0.375),motion sickness reaction(χ~2=0.787,P=0.375),seasickness reaction(χ~2=0.229,P=0.632),and tumor stage(χ~2=0.372,P=0.946)were not found to be significantly different in the comparison of basic information.(2)No significant difference was found between the incidence of nausea in the test group and the control group within 24 h after chemotherapy(χ~2=1.46,P=0.23),and no significant difference was found between the incidence of nausea in D1(χ~2=4.06,P=0.04),D2(χ~2=13.38,P<0.01),D3(χ~2=71.80,P<0.01),D4(χ~2=51.57,P<0.01),D5(χ~2=32.53,P<0.01),D6(χ~2=9.82,P<0.01).(3)The difference between the severity of nausea occurrence in the test group and the control group within 24 h after chemotherapy was significantly different(χ~2=17.42,P<0.01)in D1(χ~2=19.30,P<0.01),D2(χ~2=19.76,P<0.01),D3(χ~2=71.90,P<0.01),D4(χ~2=52.07,P<0.01),D5(χ~2=32.53,P<0.01),and D6(χ~2=9.82,P<0.01)showed significant heterogeneity in the severity of nausea in the test group compared with the control group.(4)The incidence of nausea in the test group was significantly lower than that in the control group within 24 h after chemotherapy(χ~2=35.74,P<0.01),and in D1(χ~2=66.15,P<0.01),D2(χ~2=67.65,P<0.01),D3(χ~2=85.33,P<0.01),D4(χ~2=75.23,P<0.01),D5(χ~2=40.62,P<0.01),D6(χ~2=18.78,P<0.01).The incidence of vomiting in the test group was significantly lower than that in the control group.(5)The difference between the severity of vomiting occurrence in the test group and the control group within 24 h after chemotherapy was significantly different(χ~2=47.12,P<0.01)in D1(χ~2=66.28,P<0.01),D2(χ~2=67.73,P<0.01),D3(χ~2=86.00,P<0.01),D4(χ~2=75.45,P<0.01),D5(χ~2=40.72,P<0.01),and D6(χ~2=18.78,P<0.01)showed significant heterogeneity in the severity of vomiting in the test group compared with the control group.(6)The effective rate of the treatment of acute and delayed vomiting was 100.00%in the test group and 88.89%and 81.48%in the control group,which was significantly higher in the test group than in the control group,with significant differences between the two groups(χ~2=6.35,P<0.01;χ~2=11.02,P<0.01).Conclusion:Kanlisha acupressure at Shuang Neiguan and Shen Que points could prevent the occurrence of CINV reactions,and the severity of nausea and vomiting in the test group was relieved after 24 h of Canli sand acupressure administration,and the severity of nausea occurrence in the test groups D1to D5 was lower than that in the control group.Although Kanli sand acupressure showed good relief of class I CINV symptoms,Kanli sand acupressure also showed some efficacy for type II and III CINV symptoms,but due to the limitation of the number of patients,a larger sample size of clinical studies is still needed to confirm the exact efficacy of Kanli sand acupressure for moderate to severe CINV. |
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