Observation On The Curative Effect Of Self-made Wenyang Kuijie Decoction Combined With Du Moxibustion In The Treatment Of Ulcerative Colitis With Deficiency Of Spleen And Kidney Yang

Objective:Through this clinical controlled study,the therapeutic effect and safety of self-made Wenyang Kuijie Decoction combined with Du Moxibustion on Ulcerative Colitis of spleen and kidney Yang deficiency were observed,and then the clinical value of the combination of Chinese medicine and Western medicine was evaluated,so as to provide more clinical data support and selectable treatment plan for ulcerative colitis.Methods:Sixty patients with spleen and kidney Yang deficiency UC were chosen according to the intake and discharge standard.30 patients in the treatment group and 30 patients in the control group were randomly included.The control group received mesalazine enteric-coated tablets,while the treatment group received the combination of wenyang Kujie prescription and Du Moxibustion on the basis of mesalazine enteric-coated tablets.Then the treatment lasted for four weeks.Before and after treatment,the TCM syndrome score and colonoscopic mucosal lesion classification were observed and compared between the two groups,and the TCM syndrome efficacy and colonoscopic mucosal lesion efficacy of the two groups were determined.Statistical software SPSS26.0 was used for data processing and analysis.Results:1.In terms of TCM syndromes:(1)Comparison of total curative effect of TCM syndromes: after treatment,the effective rates of TCM syndromes in the treatment group and the control group were 86.67% and 73.33%,respectively.Compared with the control group,the treatment group was better in improving the curative effect of TCM syndromes(P<0.05).(2)Comparison of total score of TCM syndromes: comparison of intra-group data showed that the test results of the two groups were all P<0.05,indicating statistical difference.Data comparison between groups showed that P<0.05,suggesting that both groups could improve the TCM symptoms of kidney Yang deficiency UC,and the therapeutic effect of the treatment group was prominently better than the other group.(3)Single scores comparison of TCM syndromes: intra-group data comparison showed that the improvement of main symptoms(diarrhea,bloody purulent stool,abdominal pain,chills and cold limbs)and secondary symptoms(flatulence in the belly,inappetence,soreness and debilitation of waist and knees)in both groups showed P<0.05,illustrating that both groups have a definite therapeutic efficacy.Data comparison between groups displayed that the treatment group had more advantages in improving bloody purulent stool,chills and cold limbs,inappetence,soreness and debilitation of waist and knees(P <0.05).In the therapy of diarrhea,abdominal pain and flatulence in the belly,the two groups had semblable therapeutic efficacies(P>0.05).2.In terms of mucosal lesions under colonoscopy:(1)Comparison of total effective rates of mucosal lesions under colonoscopy: after treatment,the effective rates of the treatment group and the control group were 66.67% and60.00% respectively.Comparison of data between groups showed P>0.05,indicating that the two groups had semblable therapeutic efficacies on mucosal lesions.(2)Comparison of lesion classification under colonoscopy:comparison of intra-group data displayed that P<0.05 was found in both groups,indicating the existence of statistical differences.Comparison of data between groups showed that P>0.05,indicating that both groups could reduce the grading of patients’ colonoscopic lesions,and the two groups had semblable therapeutic efficacies.3.Safety:We did not find any adverse events in patients during the trial,and the signs of life were normal before and after treatment.No distinct abnormalities were found in the safety indicators such as three routine examinations in the laboratory、liver and renal function.Conclusion:The self-made Wenyang Kuijie Decoction combined with Du Moxibustion for the treatment of Ulcerative Colitis with spleen and kidney Yang deficiency can effectively improve the symptoms of TCM and intestinal mucosal lesions of patients,and has satisfactory safety in the treatment process,which is worthy of further clinical research,application and promotion.