Spleen Yang Soup Spleen And Kidney Yang Patients With Ulcerative Colitis Clinical Study Immune Function

purpose : to observe the study explored the spleen decoction on spleen and kidney Yang deficiency type of mild and moderate ulcerative colitis therapy effect, as well as the patients before and after treatment serum levels of T cell subsets(CD4 +, CD8 +, CD4 +/ CD8 +), blood cell factor(IL- 10, TNF- a) the change of the content, and to explore its mechanism of action, and provide research foundation for the further research in the future.Methods: 60 cases of spleen and kidney Yang deficiency type of mild and moderate ulcerative colitis patients were randomly divided into treatment group and control group,30 cases in each group. Oral Chinese medicine treatment group explored spleen decoction, the control group oral beauty salad lamictal tablets, two groups all use proprietary Chinese medicine granules enteritis I retention enema, course of treatment for 8 weeks. Observe two groups before and after treatment of traditional Chinese medicine symptoms, electronic colonoscopy under mirror scoring, disease activity index(DAI), serum levels of T cell subsets(CD4 +, CD8 +, CD4 + / CD8 +), blood cell factor IL- 10 and the change of TNF- a content. All data using SPSS17.0 statistical software package for processing.Results:(1) group of two groups before and after treatment of traditional Chinese medicine main symptom integral comparison, significant differences(P < 0.01); After treatment, compared the difference was statistically significant(P < 0.05).(2) the two groups before treatment disease activity index(DAI) evaluation score(P > 0.05),comparable. The score after treatment(P < 0.01), significant differences.(3) two groups group colonoscopy mucous membrane mirror under the integral comparison before and after the treatment, there is a very significant difference(P < 0.01); Compare two groups after treatment, the difference was statistically significant(P < 0.05).(4) two groups after treatment, respectively, and their CD4 + compared before treatment, there was no statistically significant difference(P > 0.05).(5) group in the 2 groups werecompared before and after treatment of CD8 +, there are significant difference statistically significant(P < 0.01); Compare two groups after treatment, with significant difference(P < 0.01).(6) group in the 2 groups were compared before and after treatment of CD4 + / CD8 +, there are significant difference statistically significant(P <0.01); Compare two groups after treatment, with significant difference(P < 0.01).(7)fellow TNF- a comparison before and after the treatment, two groups have significant difference(P < 0.01); Compared two groups after treatment, the difference was statistically significant(P < 0.05).(8) two groups treatment group before and after IL-10, in contrast, there are significant difference statistically significant(P < 0.01);Compared two groups after treatment, the difference was statistically significant(P < 0.05).(9) two groups after treatment in patients with comprehensive evaluation of clinical curative effect comparison, the difference was statistically significant(P < 0.05).(10)drug safety observation found no abnormalities.Conclusion: in the treatment group, the improvement of immune observation of clinical symptoms and signs, such as colonoscopy effect were better than the control group;Wenyang Jianpi Decoction on spleen kidney yang deficiency type mild, moderate UC patients curative effect; Wenyang Jianpi Decoction can regulate the immune, reduce inflammation, antibacterial effect; Wenyang Jianpi Decoction has the repair of intestinal mucosa injury; Wenyang Jianpi Decoction drug safety.