Clinical Study On Modified Banxia Baizhu Tianma Decoction In The Treatment Of Insomnia(Phlegm Turbidity And Blood Stasis Syndrome) After Cerebral Infarction

Objective: To observe the clinical efficacy,safety and adverse reactions of Banxia Baizhu Tianma Decoction in the treatment of insomnia(phlegm turbidity and blood stasis syndrome)after cerebral infarction.The sleep quality,TCMSS and neurological recovery of patients before and after treatment were statistically analyzed to explore the role of Banxia Baizhu Tianma Decoction in the treatment of insomnia after cerebral infarction.Methods: 66 patients diagnosed with post-cerebral infarctio n insomnia(phlegm turbidity and blood stasis syndrome)were sel ected and randomly divided into a treatment group and a control group with 33 cases in each group.Except for the specialized ba sic treatment of cerebrovascular diseases,the patients in both groups took zopiclone tablets orally before going to bed.On thi s basis,the treatment group was additionally given Chinese herba l decoction Banxia Baizhu Tianma Decoction.The formula was: Pin ellia ternary 9g,Atractylodes macrocephala 15 g,Gastrodia elata 24g,Exocarpium Citri Grandis 5g,Poria cocos 30 g,rhizome of ch uanxiong 15 g,Earthworm 9g,Fried sour jujube kernel 30 g,Noctur nal vine 15 g,Polygala tenuifolia 9g,Glycyrrhiza uralensis 6g.T he changes of Pittsburgh sleep quality index(PSQI),National In stitutes of Health Stroke Scale(NIHSS)score and Traditional Ch inese Medicine Syndrome Scores(TCMSS)were observed and comparedbetween the two groups before and after treatment.The course o f treatment was 3 weeks.Result:(1)NIHSS score comparison: after treatment,the neurologic al function score of the two groups was not significantly lower than that before treatment(P>0.05),and there was no significan t difference between the treatment group and the control group(P>0.05).(2)Comparison of PSQI: compared with that before treatment,the scores of the two groups decreased in varying degrees(P<0.05).There was no significant difference between the two groups in terms of sleep time,sleep disorder and the use of hypnotic drugs(P>0.05).In terms of sleep quality,sleep time,sleep efficiency and daytime function,the score of the treatment group decreased more than that of the control group(P<0.05).(3)Comparison of TCMSS: the TCMSS of the two groups were im proved after treatment,and the treatment group was better than the control group(P<0.05).The main symptoms and secondary syndr omes of the two groups were improved after treatment,but there was no significant difference between the two groups in improvin g tongue deviation(P>0.05).The improvement of the treatment gr oup was better than that of the control group(P< 0.05).(4)Comparison of curative effects: the total clinical curative effect was 87.5% in the treatment group and 75% in the control group.The two groups could improve the sleep of insomnia patients after cerebral infarction,and there was significant difference(P<0.05).The total effective rate of TCMSS in the treatment group was 93.75%,which was better than 81.25% in the control group.(5)Comparison of safety and adverse reactions: the relevant safety indexes of the two groups were within the safe range before and after treatment,and no serious adverse reactions were found.Conclusion: The addition and subtraction of Banxia Baizhu Tianma decoction has no obvious advantage in the recovery of neurological function in patients with cerebral infarction,but it can effectively improve the sleep situation of patients,which is specifically reflected in reducing the sleep quality,sleep time,sleep efficiency and daytime function in PSQI.At the same time,this method can significantly improve the clinical symptoms of patients(insomnia,daytime drowsiness,epigastric tightness,nausea and vomiting,loss of appetite).No obvious adverse reactions and side effects were found during the treatment,which is suitable for clinical application.