Clinical Research Of Modified Huanglian Ejiao Decoction In The Treatment And Its Influence On Life Quality Of Insomnia With Yin Deficiency And Fire Hyperactivity In Postmenopausal Syndrome

Objective:To study the clinical effect of modified Huanglian Ejiao Decoction on Insomnia with Yin Deficiency and Fire Hyperactivity in Postmenopausal Syndrome and the impact on patients’life quality.So as to provide clinical basis for clinical diagnosis and treatment of this disease.Methods:60 patients with insomnia due to menopausal syndrome of yin deficiency and fire hyperactivity were selected from June 2020 to October 2021in the Gynecology Clinic of the Affiliated Hospital of Shandong University of Chinese Medicine.They were randomly divided into control team and experimental team.The experimental team was orally administrated modified Huanglian Ejiao Decoction,while the control team was treated with Nüzhen Granule.After continuous treatment for four weeks,the changes of Pittsburgh sleep quality index（PSQI）score,modified Kupperman score,WHOQOL-BREF score,Traditional Chinese Medicine（TCM）syndrome score,serum estradiol（E₂）level and follicle stimulating hormone（FSH）level in the two teams were analyzed.Follow up to learn about recurrence of insomnia after patient discontinuation.Results:Before remedy,there was no meaningful discrepancy between the two teams in the total grade of PSQI and its various factors,modified Kupperman grade,TCM syndrome grades,WHOQOL-BREF grades and serum sex hormone levels（P>0.05）,which was comparable.After treatment,the two teams of treatment can improve the patient’s total PSQI score and its various factor scores,modified Kupperman score,TCM syndrome score,WHOQOL-BREF scores in various fields.The effect of the experimental team be preferable to that of the control team,the difference was statistically significant（P<0.01 or P<0.05）;The sleep cure rates of the control team and the experimental team were 63.33%and 93.33%,（P<0.01）.The TCM cure rates of the two teams were76.67%and 96.67%,respectively.（P<0.05）.The postmenopausal cure rates of the two teams were 66.67%and 93.33%,respectively.（P<0.05）The serum E₂level increased and the FSH level decreased in the two teams（P<0.01）.The patients were followed up four weeks after the treatment.The relapse rates of the experimental team and the control team were 6.67%and 30.00%（P<0.05）.Conclusion:Modified Huanglian Ejiao Decoction can effectively alleviate the symptoms of insomnia and menopausal syndrome,alleviate TCM clinical symptoms,improve the level of sex hormones,and roundly improve the patients’life quality.In addition,the long-term recurrence rate is low.