Clinical Observation Of Danggui Liuhuang Decoction In The Treatment Of Insomnia (Hyperactivity Of Fire Due To Yin Deficiency Syndrome)

Objective:In this study,Danggui Liuhuang Decoction was used to treatment insomnia(hyperactivity of fire due to yin deficiency syndrome),so as to objectively evaluate the clinical efficacy and safety of Danggui Liuhuang Decoction on patients of insomnia(hyperactivity of fire due to yin deficiency syndrome).Methods:In this study,66 patients with insomnia(hyperactivity of fire due to yin deficiency syndrome)were selected from January 2022 to December 2022 in the Second Outpatient Department of Internal Medicine of the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine.According to the random number table method,they were divided into the treatment group and the control group according to the principle of 1:1,with 33 patients in each group.The treatment group was treated with Danggui Liuhuang Decoction,one dose per day;Patients in the control group were treated with eszopiclone tablets,3mg daily,and the course of treatment was 28 days for both groups.The scores of Pittsburgh Sleep Quality Index(PSQI)scale,TCM Syndrome Scale,Insomnia Severity Index(ISI)scale,Chinese Quality of Life(ChQOL)scale and clinical efficacy were evaluated and recorded on the 0th day and 28th day of treatment.SPSS26.0 was used for analysis and treatment to explore the clinical efficacy and safety of Danggui Liuhuang decoction in the treatment of insomnia(hyperactivity of fire due to yin deficiency syndrome).Results:1.Baseline data analysis:There was no significant difference in gender,age and course of disease between the two groups before treatment(P>0.05),which was comparable.2.PSQI scale score analysis:Before treatment,there was no significant difference between the two groups in the total score of PSQI and the score of each factor(P>0.05);After treatment,the two groups of patients compared with the group before treatment,the treatment group and the control group PSQI scale total score and the score of each factor were significantly reduced,with statistical difference(P<0.05);After treatment,there was no significant difference in the total score of PSQI between the two groups(P>0.05);there was significant difference in the daytime dysfunction score between the two groups(P<0.05),There was no significant difference in the scores of the remaining PSQI factors(P>0.05).3.Integral analysis of TCM syndrome scale:Before treatment,there was no significant difference in the total integral and each syndrome integral of TCM syndrome scale between the two groups(P>0.05);After treatment,compared with before treatment,the total score of TCM syndrome scale and the score of each syndrome in the treatment group were lower(P<0.05),while the total score of TCM syndrome scale and the score of syndrome such as vexation,insomnia,feverish sensation in palms and soles,amnesia,dizziness,tinnitus and palpitation in the control group were significantly lower.The difference was statistically(P<0.05).After treatment,the total score and other syndrome scores of TCM syndrome scale in the treatment group were lower than those in the control group except for vexation and insomnia,with statistical difference(P<0.05).4.Analysis of ISI and ChQOL scores:Before treatment,there was no significant difference in the scores of ISI and ChQOL between the two groups(P>0.05);after treatment,there was significant difference in the scores of ISI and ChQOL between the two groups(P<0.05);After treatment,there was no significant difference in ISI scale scores between the two groups(P>0.05),The total score and each dimension score of ChQOL scale in the treatment group were higher than those in the control group,with statistical difference(P<0.05).5.Clinical efficacy analysis:The total effective rate of the treatment group was 80.65%and that of the control group was 86.67%.There was no significant difference between the two groups(P>0.05).Conclusion:1.Modified Danggui Liuhuang Decoction can improve the overall sleep status of patients with insomnia(hyperactivity of fire due to yin deficiency syndrome)and has good safety.2.Modified Danggui Liuhuang Decoction can significantly relieve the accompanying symptoms of insomnia(hyperactivity of fire due to yin deficiency syndrome),such as vexation,insomnia,feverish sensation in the palms and soles,night sweat,dry mouth,lack of body fluid,amnesia,dizziness,tinnitus,soreness and weakness of waist and knees,and palpitation.3.Modified Danggui Liuhuang Decoction can significantly improve the quality of life of patients with insomnia(hyperactivity of fire due to yin deficiency syndrome).