To Explore TCM Master Xue Bosbou’s Experience In Diagnosis And Treatment Of Cough Medication Based On Data Mining

Objective:This paper aims to collect and sort out the cases of cough treated by the master of Traditional Chinese medicine Xue Boshou,use data mining to explore the medication in the treatment of cough,and summarize characteristics and thoughts of Xue Boshou on syndrome differentiation and treatment of cough,in order to provide reference for clinical diagnosis and treatment of cough and improve the therapeutic effect of cough.Methods:Based on the inheritance management and service platform of famous doctors,the cough case data of patients diagnosed and treated by TCM master Xue Boshou from 1980 to 2022 were collected,and then the data were input into the system according to the structured case collection list.The case data were exported to Excel spreadsheets after verification.After processing,the case data was further normalized by ETL software.Excel was used for frequency statistical analysis of standardized symptoms,tongue demonstrations and pulse condition,syndrome type of TCM,treatments,prescriptions and Traditional Chinese medicine.IBM SPSS Modeler 18 was used for drug association rule analysis.The drug data with frequency≥ 50 times were imported into SPSS25.0 for cluster analysis and new prescriptions were obtained.Gephi was used for complex network analysis of herbs.Results:1.In this study,a total of 206 patients with cough were collected with 364 consultations,of which 112 were male,accounting for 54.4%of the total,and 94 were female,accounting for 45.6%of the total.In terms of age distribution,most cough patients were children,35.92%under 10 years old.2.Symptom presentation:A total of 448 symptoms were described after normalization,with a total frequency of 4525 in 364 consultations.The frequency of positive symptoms were cough(335 times),expectoration(213 times),fever(90 times),poor sleep(77 times),poor appetite(74 times),nasal obstruction(65 times),and difficult expectoration(64 times),etc.There were 17 tongue types,and the top 5 most frequent tongue types were red tongue(183 times),light red tongue(54 times),dark red tongue(35 times),fat big tongue(21 times),light tongue,(14 times).There were 27 kinds of tongue coating,and top 10 most frequent tongue coating were white coating on the tongue(123 times),yellow coating on the tongue(70 times),greasy coating(40 times),thin coating(37 times),thick greasy coating(13 times),and yellow greasy tongue coating(12 times),thin white greasy coating(12 times),thin greasy coating(11 times),peeled coating(10 times).After dissecting the compound pulse conditions into a single pulse condition,there were 11 kinds of pulse conditions.According to the frequency of pulse conditions,they were smooth pulse(115 times),wiry pulse(102 times),thin pulse(87 times),rapid pulse(67 times),deep pulse(47 times),weak pulse(37 times),floating pulse(33 times),feeble pulse(10 times),soft pulse(8 times),uneven pulse(6 times),moderate pulse(5 times).3.Frequency of syndrome types:After standardization,the top 5 most frequent of syndrome types were wind-cold transforming into heat(88 times),wind-cold affecting lung(50 times),wind-heat affecting lung(48 times),phlegm-heat storing in lung(48 times),phlegm-damp obstructing of lung(34 times).4.Frequency of prescriptions:a total of 86 kinds of prescriptions were used in this study,and the top 10 were Zhisou Powder(80 times),Sini Powder(79 times),Shengjiang Powder(49 times),Xiaochaihu Decoction(48 times),Sanao Decoction(44 times),Sangju Yin(39 times),Qianjin Weijing Decoction(37 times),Yinqiao Powder(37 times),Suchen Jiubao Decoction(34 times),and Suzi Jiangqi Decoction(33 times).5.Frequency of treatment:Among the 364 cases of cough,the frequency of treatment was 89 treatments,such as promoting lung and relieving cough(141 times),dispersing wind and heat(127 times),dispersing wind and cold(90 times),resolving phlegm and relieving cough(54 times),clearing heat and eliminating phlegm(53 times).6.Frequency of herbs:A total of 204 Chinese medicinal herbs were used in this study,and the frequency of more than 150 times were as following:Semen Armeniacae Amarum(261 times),Radix Platycodonis(252 times),Periostracum Cicadae(231 times),Fructus Forsythiae(198 times),Radix Glycyrrhizae(195 times),Radix Saposhnikoviae(173 times),Radix Peucedani(169 times),Radix Bupleuri(163 times).Among them,80 kinds of property of herbs were warm,with a total frequency of 2184,68 kinds of property of herbs were cold,with a total frequency of 2184,11 kinds of property of herbs were cool,with a frequency of 189,31 property of herbs were flat,with a frequency of 963,and 6 kinds of property of herbs were heat.Bitter herbs accounted for the largest proportion of the five flavors.The frequency of TCM was bitter>pungent>sweet>sour>light>salty>astringent.According to the analysis of TCM meridian theory,lung meridian herbs,spleen meridian herbs,stomach meridian herbs were the most frequently used.The top four herbs in the frequency of TCM efficacy were exterior-releasing herbs(1438 times),reducing phlegm,relieving cough and antiasthmatic herbs(1062 times),clearing heat herbs(990 times)and tonifying deficiency herbs(796 times).7.Analysis of high-frequency drug association rules:The highest supporting degree of cough medication combination was Radix Platycodonis and Periostracum Cicadae(63.462%),followed by Radix Platycodonis and Radix Peucedani,Semen Armeniacae Amarum and Radix Peucedani.8.Cluster analysis of new prescriptions:①Radix Bupleuri,Fructus Aurantii,R adi-x Paeoniae Alba;②Radix Saposhnikoviae,Fructus Mume,Periostracum Cica d-ae;③Radix Asteris,Folium Eriobotryae,Radix Platycodonis,Radix Peucedani;④F-ructus Jujubae,Rhizoma Zingiberis Recens,Radix Scutellariae;⑤Rhizoma P inel-liae,Poria,Cortex Magnoliae Officinalis.9.Complex network analysis of new prescriptions:Bulbus Fritillariae Thunbergii,Rhizoma Pinelliae,Cortex Magnoliae Officinalis,Semen Armeniacae Amarum.Conclusion:In the aspect of syndrome differentiation and treatment,Xue Boshou,a master of Chinese medicine,pays attention to the combination of four diagnoses,the nature of cough and expectoration,as well as the accompanying symptoms and mixed syndromes.Exogenous cough should be paid more attention to explore the causes of the disease and the internal injury cough should be focused on phlegm;In terms of treatment,exogenous cough should be attached importance to dispersing lung and penetrating evil and the internal injury cough should be treated from the liver and lung,regulate qi activity,and pay attention to the spleen and stomach.In the use of Traditional Chinese medicine,therapy combined cooling and warming should be used,and herbs should be light and peaceful,safe and non-toxic.