Predictive Analysis Of Related Risk Factors In Delayed Encephalopathy Caused By Acute Carbon Monoxide Poisoning

ObjectiveFind out the related risk factors of delayed encephalopathy after acute carbon monoxide poisoning(DEACMP),give high attention to patients who combine these risk factors in clinical treatment,and actively treat to reduce the occurrence of this disease.It provides a basis for the prevention of acute carbon monoxide poisoning and delayed encephalopathy,early detection and early treatment,so as to improve the quality of life of patients and reduce the economic burden of society.MethodsThe patients who were treated in the First Affiliated Hospital of Zhengzhou University for acute carbon monoxide poisoning were analyzed retrospectively.The sex,age,work type,smoking history,basic diseases,coma time,early ECG,early computed tomography(CT)/magnetic resonance imaging were recorded in detail,MRI)manifestations,early leukocyte count,early C-reactive protein,early glutamic transaminase,early aspartate transaminase,follow-up by telephone,to register the survival,prognosis of the disease,and whether there is delayed encephalopathy.The patients who did not have delayed encephalopathy were classified as non delayed encephalopathy group,and those who had delayed encephalopathy were classified as delayed encephalopathy group.The patients were divided into delayed encephalopathy group,and in gender,age,work type,smoking history,previous basic diseases,coma time,early ECG,early CT/MRI manifestations of head,early white blood cell count,early C-reactive protein,early glutamic transaminase The single factor analysis was carried out on enzyme,early aspartate transaminase and other aspects,and the risk factors for predicting delayed encephalopathy of acute carbon monoxide poisoning were screened out.The variables with statistical significance were analyzed by two classification logistic regression.In this study,SPSS 21.0 statistical software is used to input and analyze the data.For the counting data,the composition ratio is used to represent the data,and the chi square(x2)test is used to compare the two groups of counting data.For the measurement data,after the advanced normal distribution test,the non normal data are not subject to normal,and the average rank is compared by nonparametric test and rank combination test.The variance homogeneity test is conducted for the measurement data which is subject to normal distribution;if the variance is identical,the difference between the two groups is compared with that of t test;if the variance is not homogeneous,the difference between the two groups is compared with the T ’test,and the results are shown by mean±standard deviation.The above method was used to screen single factor,and the items with statistical differences were regarded as independent variables(x),whether there was delayed encephalopathy as dependent variable(y)for logistic regression analysis of two categories and multi factor analysis.P<0.05 was statistically significant.ResultThe results of single factor analysis showed that the difference of age 45 years or older,mental work,history of hypertension and/or diabetes mellitus,smoking history,coma duration is at least 24 hours,early ST-segment changes in electrocardiogram,early abnormal head CT/MRI,and early abnormal C-reactive protein levelwere statistically significant(P<0.05),which was an independent risk factor for predicting delayed encephalopathy.There was no significant difference in sex,early leukocyte count,early GLT and early aspartate transaminase between the two groups(P>0.05),which was not an independent risk factor for predicting delayed encephalopathy.By consulting the literature,the factors that may lead to investigation bias were excluded.Finally,age,previous basic diseases,smoking history,coma time and early ct/mri of skull were included in multivariate logistic regression analysis.The results showed that the age and the length of coma time were positively correlated with the incidence of delayed encephalopathy.ConclusionAge 45 years or older,mental work,history of hypertension and/or diabetes mellitus,smoking history,coma duration is at least 24 hours,early ST-segment changes in electrocardiogram,early abnormal head CT/MRI,and early abnormal C-reactive protein level were independent risk factors for delayed encephalopathy caused by acute carbon monoxide poisoning.Age,coma time were positively correlated with the onset of delayed encephalopathy.There are many risk factors that lead to the occurrence of delayed encephalopathy of acute carbon monoxide poisoning.For patients with acute carbon monoxide poisoning accompanied by these risk factors,high attention should be paid to the clinical treatment,and active treatment should be given in the early stage to reduce the occurrence of the disease,improve the quality of life of patients and reduce the pressure of family and society.