Correlation Of Fib,LDH,D-D With Delayed Encephalopathy After Acute Carbon Monoxide Poisoning

Objective:To explore the correlation between first emergency examination results and delayed encephalopathy of moderate and severe acute carbon monoxide poisoningMethods:A retrospective analysis of 199 patients with moderate to severe acute carbon monoxide poisoning presenting to the emergency department of Baoding First Central Hospital from January 2016 to December 2021.According to the DEACMP diagnostic criteria,divided into two groups: 40 patients in DEACMP group and 159 patients in non-DEACMP group,analyse the difference between the first emergency examination results after admission between the two groups and the association with DEACMP.Compare the general data between the two groups: age,gender,type of labor,underlying diseases(diabetes,coronary heart disease,hypertension,cerebral infarction,cerebral hemorrhage);Laboratory index:NLR,WBC,NLR,PT,APTT,TT,Fib,CK,CK-MB,LDH,p H,COHb,D-D,Lac;Imaging examination: the results of first brain CT of the patient after admission;And a multivariate Logistic regression analysis of the independent risk factors for DEACMP.Measurement data conforming to the normal distribution are represented by ` c ±s,comparison between the two groups by independent sample t-test,Measures that do not conform to the normal distribution are expressed as M(P25,P75),and the comparison between the two groups is performed by the Mann-Whitney U test.Count data were expressed as frequency(percentage)and compared between two groups by c 2 test or Fisher’s exact test.Correlation analysis was performed using Spearman.Multivariate logistic regression was applied to analyze the independent factors affecting DEACMP.ROC and AUC were used to evaluate the early prediction efficacy of DEACMP.the difference was statistically significant(P < 0.05).Results:1.Comparison of general clinical data in age,sex,type of labor,hypertension,diabetes,coronary heart disease,cerebral infarction,and cerebral hemorrhage between the two groups,no differences were statistically significant(P>0.05).The proportion of severe ACMP was significantly higher than that in the non-DEACMP group(P < 0.05).2.Comparison of the first emergency laboratory indicators in the two groups: WBC,NLR,FIB,CK,CKMB,LDH,D-D and Lac levels were higher in the DEACMP group than the non-DEACMP group,with statistically significant differences(P < 0.05).3.Comparing the results of the first emergency brain head CT examination in the two groups,the abnormal rate of CT examination results of the patients in the DEACMP group was higher than that of the non-DEACMP group,and the difference was statistically significant(P <0.05).4.Spearman Correlation analysis showed that severe poisoning,WBC count,NLR,Fib,CK,CKMB,LDH,D-D,Lac,and head CT results were positively associated with the occurrence of DEACMP(P < 0.05).5.The results of multivariate Logistic analysis show that Fib,D-D and Lac are possible independent influencing factors of DEACMP(P < 0.05).6.The ROC curve showed that the prediction efficacy of Fib + D-D +Lac on DEACMP was better than Fib + D-D,Fib + Lac,D-D + Lac and single index(P < 0.05).Conclusions:Elevated serum levels of Fib,D-D,and Lac are possible independent risk factors for the development of DEACMP.The combination of Fib + D-D + Lac was better to predict the occurrence of DEACMP than Fib + D-D,Fib + Lac,D-D + Lac and single index.