Correlation Study Of Traditional Mongolian Medicine Sa Syndromes And Serum Markers Of Cerebrovascular Diseases In Patients With Cerebral Infarction

Objective: In order to investigate the component of Traditional Mongolian Medical(TMM)Sa syndrome types in patients with cerebral infarction(CI),and provide the possible association between the TMM Sa syndrome and CI.Provide scientific rationale for the diagnosis and treatment for CI patients in integrated TMM and western medicine.And to explore the advanced for establishing a efficacy,comprehensive and standardized TMM syndrome differentiation system for patients with CI.Method: After strict inclusion and exclusion criteria based on TMM and western medicine,a total of 371 patients met the requirements in our study.According to clinical history,symptoms,and based on the TMM ten diagnostic criteria,we categorized the patient as Qisu bias,Hei Sira bias,Badgan Hei bias,Sira Wusu bias and Badgan Sira bias.Serological indicators such as hs-CRP、TC、TG、LDL-C、HDL-C、Hcy、UA was collected,subgroup statistics were conducted according to age,sex and clinical characteristics.Statistical methods,such as variance analysis,chi-square test and binary logistic regression analysis were used to discuss the distribution of Mongolian medical constitution and syndrome differentiation in the collected CI patients.Result: 1.The patients with CI were 220 males,accounting for 59.3%,and 151 females,accounting for 40.7%,and the mean age was 67.88±10.574 years,particularly the rise of population of over 60 years old.2.Badgan Hei bias patients were the most common TMM syndromes(24.26% of the total),in order of frequency,were as follows: Badgan Sira bias(23.45%),Hei Sira bias(19.68%),Qisu bias(18.6%),Sira Wusu bias(14.02%).The distribution relationship between TMM syndromes types and age has statistically significant.Badgan Hei bias has the highest average age(M=73.53,SD=9.50)while Qisu bias has the lowest average age(M=63.28,SD=11.05).3.Categorical variables were analyzed using the chi-squared test and found that 173 cases in the acute phase,92 cases in the recovery phase and 106 cases in the sequela phase.There was no significant relationship between ischemic stroke stage and TMM Sa syndrome type.4.Each TMM syndrome type was used as the dependent variable,and the serum markers of cerebrovascular diseases in patients with cerebral infarction(ischemic stroke stage)was used as the independent variable.Binary logistic regression was used to obtain the results: hs-CRP had a significant positive effect on Qisu bias(B=0.018,OR=1.018,P<0.05);TG had a significant negative effect on Badgan Sira bias(B=-0.918,OR=0.399,P<0.05);UA had a significant positive effect on the Badgan Sira bias in the acute phase(B=0.008,OR=1.008,P< 0.01).TC had a significant positive effect on the Badgan Hei bias in the recovery phase(B=2.239,OR=9.388,P<0.05);TG(B=-1.017,OR=0.310,P < 0.05)and LDL-C(B=-2.527,OR=0.080,P < 0.05)had a significant negative effect on Badgan Hei bias in the recovery phase;TG had a significant positive effect on Qisu bias in the recovery phase(B=1.018,OR=2.947,P<0.05).HDL-C had a significant negative effect on Qisu bias n the sequela phase(B=-5.803,OR=0.003,P<0.05).5.Each TMM syndrome type was used as the dependent variable,and the serum index was used as the independent variable.Binary logistic regression was used to obtain the results: UA had a significant positive effect on Badgan Sira bias(B=0.004,OR=1.004,P<0.01);TG had a significant positive effect on Qisu bias(B=0.314,OR=1.369,P<0.05);UA had a significant negative effect on Qisu bias(B=-0.004,OR=0.996,P<0.05).6.The results of one-way ANOVA and Non-parametric tests showed that there was no significant difference in the levels of serum hs-CRP,TC,TG,HDL-C,LDL-C,Hcy and UA between TMM syndrome types of CI,and patients with normal distribution(P >0.05).Conclusion: In this study,TMM syndrome types of CI are closely related to serum TG and UA levels.The higher the UA level,the higher the proportion of Badgan Sira bias;however,the higher the UA level,the lower the probability of Qisu bias.Therefore,there is a negative correlation with Badgan Sira bias and Qisu bias.The higher the level of TG,the higher the probability of Qisu bias,so there is a correlation between TG and Qisu bias.2.In this study,Qisu bias in the acute phase have a higher probability of hs-CRP.Badgan Sira bias in the acute phase have a lower probability of TG.Badgan Sira bias in the acute phase have a higher probability of UA.Badgan Hei bias in the recovery phase have a higher probability of TC.Badgan Hei bias in the recovery phase have a lower probability of TG and LDL-C.Qisu bias in the recovery phase have a higher probability of TG.Qisu bias in the sequela phase have a higher probability of HDL-C.3.According to the selected cases in this study,CI tends to occur more frequently after the age of 60,which is mainly concentrated in the age group of 60-69,followed by 70-79,accounting for 16.98% after the age of 80,which needs to be confirmed by relevant epidemiological studies of large samples.4.In this study,there are significant differences between TMM syndrome types of this disease in different genders.The proportion of males is significantly higher than that of females in Badgan Sira bias,Qisu bias and Sira Wusu bias,while Hei Sira bias has higher females proportion.5.In this study,the most common TMM syndrome in patients with CI is Badgan Hei bias,in order of frequency,were as follows: Badgan Sira bias,Hei Sira bias,Qisu bias,Sira Wusu bias.