Clinical Observation Of Chaihu Zhuaxi Decoction In The Treatment Of Lung Obstructing With Phlegm-heat In Acute Exacerbation Of Copd

Objective:To observe the clinical effect of "add or subtract chaihu zhuobai decoction" on patients with lung obstructed by phlegm-heat in acute exacerbation of chronic obstructive pulmonary disease.Methods:A total of 45 patients with lung obstructing with phlegm-heat in acute exacerbation stage of chronic obstructive pulmonary disease were included,and were divided into the experimental group and the control group.A total of 45 cases were completed,including 22 cases in the experimental group and 23 cases in the control group.In the experimental group,on the basis of western medicine treatment,the traditional Chinese medicine decoction of "chaihu cheats decoction" was added or subtracted and taken orally,1 dose per day,in two times.The control group was treated with western medicine.During hospitalization,blood gas analysis was performed on the first day of admission,the seventh day,and the first day before discharge.Blood coagulation and liver and kidney functions were detected on the first day of admission and one day before discharge,and TCM symptom score,symptom remission time and hospitalization time were recorded.Finally,the differences in TCM symptom score,symptom remission time,length of hospital stay,blood gas analysis,coagulation and other indicators between the two groups were compared.Results:(1)comparison of TCM syndromes points: there were significant differences in cough,sputum volume,sputum property,sputum difficulty and wheezing symptom points between the two groups before and after treatment(P<0.05),and the experimental group was significantly better than the control group in terms of symptom improvement.(2)comparison of the total effective rate of TCM syndromes: the total effective rate of the experimental group was 95.2%,and the total effective rate of the control group was 78.3%.After non-parametric test and chi-square test,the total effective rate of the experimental group was higher than that of the control group.In terms of clinical efficacy,the experimental group was superior to the control group.(3)days of hospitalization and days of symptom remission: the difference between the two groups was statistically significant in the number of days of hospitalization and days of symptom remission.The number of days of hospitalization and days of symptom remission in the experimental group was shorter than that in the control group.(4)blood gas analysis: there was no significant difference in PH value and Pa O2 between the two groups after treatment compared with before treatment,and there was no significant difference between the two groups after treatment.There was no statistically significant difference in Pa CO2 between the experimental group and the control group after treatment,while Pa CO2 increased in the control group after treatment(P < 0.05),and there was statistically significant difference between the groups on the 7th day after treatment and the 1st day before discharge(P < 0.05).(5)coagulation: there was no significant difference in PT between the two groups after treatment compared with before treatment,and there was no significant difference between the two groups after treatment;After treatment,there was a statistically significant difference in FIB between the two groups(P < 0.05),but there was no statistically significant difference between the two groups after treatment.After treatment,TT in the control group was significantly different from that before treatment(P < 0.05),but there was no significant difference between the two groups after treatment.After treatment,APTT of the experimental group was significantly different from that before treatment(P < 0.05),but there was no significant difference between the two groups after treatment.After treatment,d-dimer of patients in the experimental group showed a downward trend compared with that before treatment,while d-dimer of patients in the control group showed an upward trend compared with that before treatment.The differences between the two groups were statistically significant(P < 0.05),and the differences between the two groups were statistically significant(P < 0.05).(6)safety comparison: no adverse reactions occurred in the two groups during the treatment.Conclusion:(1)chaihu qinchest decoction plus or minus combined with western medicine treatment can not only improve the symptoms of cough,sputum volume,sputum property,sputum difficulty and easiness,and wheezing in patients with lung obstructing caused by sputum heat in the acute exacerbation stage of copd,but also reduce the levels of Pa CO2 and d-dimer,which may be a protective factor for the prognosis of patients.(2)combined with western medicine,chaihu chaichest decoction plus or minus has a good clinical effect,which can accelerate the relief of symptoms,shorten the length of hospitalization,and reflect the value of traditional medicine.(3)The clinical observation of chaihu chaichest decoction plus or minus is safe.