Initial Exploration On Rules Of TCM In Preventing And Treating Osteoporosis In Recent Thirty Years

According to searching literature,the paper collects Chinese and English literature of internal and external use of traditional Chinese medicines(TCM)in treating and preventing osteoporosis in recent three decades(1988-March 2018)in order to grasp the rules of TCM in preventing and treating osteoporosis and identify types of TCM treating osteoporosis in the medium and high frequency,thus providing the reference for modern clinic treatment of osteoporosis.After selecting 158 documents in line with literature inclusion and exclusion criteria,the information,such as specific names of syndrome differentiation,names of TCM prescriptions,specific medicine composition of TCM prescriptions and number of interventional cases,has been typed in Microsoft Office Excel 2016.The typing has been through the secondary data verification.SPSS clementine V12.0 has been used to analyze frequencies,such as the using frequency,property,taste and channel tropism;R x64 3.5.0 software has been adopted to analyze the association rules analysis and cluster of all medicines.The results are as follows:1.6413 documents were retrieved through relevant search terms such as“osteoporosis”.According to the literature inclusion and exclusion criteria,a total of158 documents in line with the criteria were included.These documents contained a total of 182 prescriptions,involving 128 kinds of TCM.The total using frequency of TCM was 1943.2.TCM with the highest using frequency was Radix Rehmanniae Praeparata,The total using frequency was 115 in all prescriptions,accounting for 63.19% of the total using frequency.There were 46 kinds of TCM with higher frequencies(≥10 times),and the total using frequency of these 46 kinds of TCM reached 1,732,accounting for 89.14%of the total using amount.Among the top 10 TCM in descending order of using frequency: Radix Rehmanniae Praeparata,Epimedium,Eucommia,Angelica Sinensis,Radix Achyranthis Bidentatae,Rhizoma Drynaria,Astragalus Mongholicus,Rhizoma Dioscoreae,Fructus Psoralea and Cornus Officinalis.3.TCM in preventing and treating osteoporosis involved medicine of tonifying deficiency,promoting blood circulation and removing blood stasis,expelling winddamp and clearing damp and promoting diuresis.Among them,the medicine in tonifying deficiency and promoting blood circulation and removing blood stasis was of highest using frequency.The total using frequency of the two types of TCM reached73.86%.It can be seen that the main TCM in preventing and treating osteoporosis is medicine in tonifying deficiency and promoting blood circulation and removing blood stasis,supplemented by other types of medicine.4.Among medicine in tonifying deficiency with high frequency(≥10 times)is ranked according to the descending order of using frequency: Epimedium,Eucommia,Fructus Psoralea,Radix Dipsaci,Semen Cuscutae,Cistanche,Antler Glue,Morinda Officinalis and Curculigo.The medicine in tonifying Qi with high frequency(≥10 times)was ranked in descending order of using frequency: Astragalus Mongholicus,Rhizoma Dioscoreae,Licorice,Rhizoma Atractylodis,Codonopsis Pilosula and Ginseng.The medicine in enriching the blood with high frequency(≥10 times)was in the descending order of using frequency: Radix Rehmanniae Praeparata,Angelica Sinensis,Radix Paeoniae Alba and Polygonum Multiflorum.The medicine in tonifying yin with high frequency(≥10 times)was ranked in the descending order of using frequency:Matrimony Vine,Tortoise Shell and Fructus Ligustri Lucidi.The medicine in promoting blood circulation and removing blood stasis with high frequency(≥10 times)was ranked in the descending order of using frequency: Radix Achyranthis Bidentatae,Rhizoma Drynaria,Ligusticum Wallichii,Salvia Miltiorrhiza,Safflower Carthamus,Caulis Spatholobi and Semen Persicae.5.The analysis of property,taste and channel tropism of medicine showed that high-frequency medicines were mainly based on sweet taste,mild property and channel tropism of liver,kidney and spleen.6.The support degree analysis in association rules found that the medicine pair,Eucommia and Radix Rehmanniae Praeparata,had the highest using frequency(up to68 times).Viewed from the compatibility effect of high-frequency medicines,it mainly included several major types,medicine in tonifying deficiency + promoting blood circulation and removing blood stasis,medicine in tonifying deficiency + clearing damp and promoting diuresis and medicine in tonifying deficiency + inducing astringency.Among medicines in tonifying deficiency,Radix Rehmanniae Praeparatal was generally used for compatibility.Confidence level ≥ 0.8 in the association rule shows that Radix Rehmanniae Praeparata is mostly used as the main medicine in the compatibility prescriptions.And it is relatively easy to achieve the medicine compatibility of tonfying Qi or enriching the blood or medicine in both tonifying Qi and enriching the blood.7.Among 46 kinds of TCM with high frequency in cluster,three clusters formulas can be more meaningful in clinic rational use of medicine are as follows: Salvia Miltiorrhiza,Eucommia,Rhizoma Drynariae,Radix Achyranthis Bidentatae,Epimedium,Fructus Psoralea,Radix Angelicae Pubescentis,Saposhnikovia Divaricata,Fraxinus Bungeana,Cinnamomum Cassia,Ginseng,Panax Notoginseng,Parasitic Loranthus,Asarum;Radix Paeoniae Alba,Ligusticum Wallichii,Codonopsis Pilosula,Rehmannia,Angelica Sinensis,Licorice,Morinda officinalis,Safflower Carthamus,Semen Persicae;Radix Rehmanniae Praeparata,Poria Cocos,Radix Aconiti Carmichaeli,Coxtex Moutan,Fructus Ligustri Lucidi,Rhizoma Dioscoreae,Cornus Officinalis,Rhizoma Alismatis.It is recommended to be used for the test of prevention and treatment of osteoporosis due to cold-dampness,blood stasis and channel blockage,osteoporosis due to blood stasis and osteoporosis due to kidney-yin deficiency.In conclusion,although there are many kinds of TCM for prevention and treatment of osteoporosis,the characteristics of high-frequency TCM can be obvious.In the treatment of the disease,it is generally based on medicine in tonifying deficiency,supplemented by the medicine in promoting blood circulation and removing blood stasis as well as clearing damp and promoting diuresis.It is aimed at the three organs,liver,spleen and kidney,giving consideration to both causes of stasis and dampness in attack of old illness.It fills the kidney essence,achieving the function of the spleen in transport,catharsis of the liver,the harmony of Qi and blood.Thus,it can achieve the clinic efficacy of simultaneous treatment of principal and subordinate symptoms.