Correlation Analysis Of Plasma Homocysteine And Cognitive Dysfunction In Small Cerebral Vascular Disease

Objective:To explore the correlation between plasma homocysteine（Hcy）and cognitive impairment in patients with cerebral small vessel disease（CSVD）.Methods:In this study,from January 2021 to December 2021,156 CSVD patients with complete clinical data and imaging data were selected from the inpatients in the Department of Neurology,China-Japan Friendship Hospital of Jilin University.Mini-mental state examination（MMSE）and Montreal cognitive assessment（MOCA）test,to assess the cognitive function of patients.According to the MOCA score,CSVD patients were divided into two groups,cognitive dysfunction group（MOCA<26 points,n=86）and non-cognitive dysfunction group（MOCA≥26 points,n=70）.The general clinical data of the two groups of patients,including Hcy,triglyceride,total cholesterol,low-density lipoprotein,uric acid,glycosylated hemoglobin,fasting blood glucose,etc.,were collected to study the correlation between the above clinical factors and cognitive dysfunction in CSVD.SPSS 25.0 was used for statistical analysis,and P<0.05 was considered statistically significant.Result:1.Hcy level and years of education between the non-cognitive dysfunction group and the cognitive impairment group,the difference was statistically significant（P<0.05）;age,gender,smoking history,drinking history,hypertension,diabetes,uric acid,fasting There was no significant difference in blood glucose,triglyceride,total cholesterol,low density lipoprotein and glycosylated hemoglobin between the non-cognitive dysfunction group and the cognitive impairment group（P>0.05）.2.Binary multivariate Logistic regression analysis showed that Hcy was an independent risk factor for cognitive impairment in CSVD.3.The visuospatial executive ability,naming,attention,calculation,language,abstraction,delayed memory and orientation in the non-cognitive dysfunction group were higher than those in the cognitive impairment group,and the differences were statistically significant（P<0.05）.4.Spearman correlation results showed that Hcy level was negatively correlated with MOCA total score,MMSE score,visuospatial executive function,language,abstraction,and delayed memory（P<0.05）;it was not correlated with naming,attention,calculation,and orientation.（P>0.05）.Conclusion:Hyperhomocysteinemia is an independent risk factor for cognitive dysfunction in CSVD,which mainly affects visuospatial executive function,language,abstraction,and delayed memory.