| Objectives To study the tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)expression in the patient’s serum who had functional dyspepsia(FD)with weight loss,and to evaluate the anxiety,depression,symptoms and life quality scores of FD patients with weight loss,and to explore the comprehensive efficacy and possible mechanism of mirtazapine in the treatment of FD patients with weight loss.Methods 30 cases of FD patients(FD group)who were included in the outpatient and inpatient departments of Hebei General Hospital from June 2020 to December 2020,the above-mentioned patients met the Rome IV diagnostic criteria and have lost≥5%weight in the past 12 months or less since the onset of disease.At the same time,30 cases of healthy population(Group N)from Hebei General Physical Examination Center.12 case of patients(M group)who are in the FD group and completed the follow-up after 4 weeks of treatment with mirtazapine.Record relevant clinical data and collect serum samples.The fasting serum TNF-αand IL-6 levels were detected by enzyme-linked immunosorbent assay(ELISA).Self-rating anxiety scale(SAS),self-rating depression scale(SDS),nepean dyspeptic symptoms index(NDSI)and nepean dyspeptic life quality index(NDLQI)were scored.In this study,SPSS25.0 statistical software was used to analyze the data.Chi-square test(χ~2test)was used for counting data.The measurement data were expressed by mean±standard deviation(?x±s).The comparison between the two groups was carried out by group design t test,and the correlation analysis was carried out by Pearson correlation analysis.Results 1 The age,BMI and gender of FD group and N group were consistent,and the differences were not statistically significant(P>0.05).2 Serum TNF-αand IL-6 levels in FD group were higher than those in N group(P<0.05).3 The scores of SAS,SDS and NDSI in FD group were higher than those in N group(P<0.05),and the scores of NDLQI in FD group were lower than those in N group(P<0.05).4 Comparison of serum indexes and scores of each scale before and after treatment in group M:The levels of serum TNF-αand IL-6 in group M decreased after treatment(P<0.05);The scores of SAS,SDS and NDSI in group M were lower than without treatment(P<0.05);After treatment,NDLQI in group M was higher than before(P<0.05).5 Serum TNF-αlevel was positively correlated with SAS and SDS(P<0.05),but not with NDSI and NDLQI(P>0.05).6 Serum IL-6levels were positively correlated with SAS,SDS and NDSI(P<0.05),and negatively correlated with NDLQI(P<0.05).Conclusions 1 The serum levels of TNF-αand IL-6 in FD patients with weight loss are higher than those in healthy people,and anxiety and depression are common,dyspepsia symptoms are severe,and the life quality is poor.2 The levels of serum TNF-αand IL-6 in FD patients with weight loss are correlated with anxiety and depression,and the levels decrease after mirtazapine is given,which indicates that TNF-αand IL-6 may participate in the regulation of mental and psychological factors in FD patients.What’s more,it can be used as objective indicators to guide diagnosis and treatment.3 The serum IL-6 level of FD patients with weight loss is related to the symptoms and life quality of patients.It is speculated that IL-6 may participate in the pathogenesis of FD and may be related to the changes of FD.4 Mirtazapine treatment can significantly improve the symptoms and emotional disorders of FD patients with weight loss,and improve the life quality of patients.Figure 0;Table 5;Reference 140... |
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