Effect Dingxuanpingya Prescription On Clinical Efficacy And Pulsein Of Patients With Syndrome Of Wind-phlegm Invading Upward Of Essential Hypertension

Objective:To study the effect Dingxuanpingya prescription on clinical efficacy and pulsein of patients with syndrome of wind-phlegm invading upward of essential hypertension.And to investigate the efficacy and safety of Dingxuanpingya prescription compared with Qianglidingxuan tablet and simple basic medical treatment in the treatment of essential hypertension with syndrome of wind-phlegm invading upward.Methods:Considering the possibility of case dropping,A total of 108 patients with essential hypertension with syndrome of wind-phlegm invading upward conform to this study were selected and randomly assigned to treatment group A,treatment group B and control group C,with 36 cases in each group.Treatment group A was given oral Dingxuan pingya prescription plus basic medical treatment,treatment group B was given oral Qianglidingxuan tablet plus basic medical treatment,and control group C was given basic medical treatment,with A course of 11 days.The changes of TCM syndrome scores,blood pressure,NICOM indexes,Daiseng diagnostic instrument indexes and safety indexes of patients in the three groups before treatment and on the 11 th day of treatment were compared,and the effectiveness and safety of the trial scheme were evaluated.Result:1.Comparison results of before treatment:(1)There was no statistical significance in TCM syndrome score,blood pressure,Nicom index and Daiseng diagnostic instrument index data of the three groups of patients before treatment(P>0.05),indicating that there were no differences in observed indexes between the three groups before treatment,which were comparable.2.Intra-group comparison before and after treatment:(1)The results of TCM syndrome score test of the three groups before and after treatment showed that there was significant statistical significance in treatment group A(P<0.01);There was statistical significance in treatment group B and control group C(P<0.05).(2)Blood pressure test results of the three groups before and after treatment showed that there was significant statistical significance in treatment group A and B(P<0.01);C test in control group was statistically significant(P<0.05).(3)The results of Nicom indexes in the three groups before and after treatment showed that there was statistical significance in treatment group A(P<0.01);The cardiac index and total peripheral resistance in the treatment group B were statistically significant(P<0.01),and the cardiac output,cardiac power and stroke output were statistically significant(P<0.05).In the control group C,the total peripheral resistance was statistically significant(P<0.05),while the cardiac index,cardiac output,cardiac power and stroke output were not statistically significant(P>0.05).(4)The test results of Daiseng diagnostic instrument showed that in treatment group A,vascular tension of h3/h1 and peripheral resistance of h4/ h1 were statistically significant(P<0.01),pulse strength of h1 was statistically significant(P<0.05),and left ventricular systolic function of t1 was not statistically significant(P>0.05).In treatment group B,the results of vascular tension of h3/h1 and peripheral resistance of h4/ h1 were statistically significant(P<0.05),while the results of pulse strength of h1 and left ventricular systolic function of t1 were not statistically significant(P>0.05).In the control group C,the results of h4/ h1 peripheral resistance were statistically significant(P<0.05),while the results of h1 pulse strength,h3/h1 vascular tension and t1 left ventricular systolic function were not statistically significant(P>0.05).3.Results of comparison between groups after treatment:(1)The TCM syndrome score after treatment was statistically significant(P < 0.05).(2)Blood pressure: systolic blood pressure after treatment was not statistically significant(P > 0.05);The results of diastolic blood pressure were statistically significant(P < 0.01).(3)The NICOM indexes were statistically significant(P < 0.01).(4)Daiseng diagnostic instrument index : H1 pulse strength,H4 / H1 peripheral resistance had significant statistical significance(P < 0.05),H3 / H1 vascular tension had significant statistical significance(P < 0.01),T1 left ventricular contraction power had no significant statistical significance(P > 0.05)4.Results of safety indexes comparison:(1)There was no statistical significance in the liver and kidney function test results of the three groups before and after treatment(P>0.05).(2)All the patients participating in this study did not have allergies or adverse reactions related to experimental drugs during treatment.Conclusion: Dingxuanpingya prescription has a significant effect on the improvement of blood pressure,NICOM indexes,and Daiseng diagnostic instrument indexes of in essential hypertension patients with syndrome of wind-phlegm invading upward.It can improve patients’ cardiac output,cardiac index,stroke output and cardiac power.Increasing h1 pulse strength,decreasing total peripheral resistance,h3/h1 vascular tension,and h4/ h1 peripheral resistance,did not significantly improve the left ventricular systolic function of t1.Dingxuanpingya prescription plus basic medical treatment has obvious advantages compared with Qianglidingxuan tablet plus basic medical treatment and simple basic medical treatment in treating the syndrome of wind-phlegm invading upward of essential hypertension,and it is safe to use.