| Purpose:Observation of Jianpi Tongluo Recipe on clinical symptoms and renal proximal tubule damage indicators of patients with spleen deficiency and blood stasis type Ⅲ diabetic nephropathy: serum retinol binding protein,serum α1-microglobulin,urine N-acetyl-β-DGlucosaminidase;glomerular filtration rate damage indicators: serum β2-microglobulin,serum α2-macroglobulin;renal function: blood urea nitrogen,blood creatinine,24-hour urine protein quantification,blood sugar: fasting blood sugar,breakfast The effect of blood glucose and glycosylated hemoglobin after 2h was evaluated for its clinical efficacy and safety.Method:According to the random number table method,72 patients with spleen deficiency and blood stasis type Ⅲ DKD were divided into treatment group and control group,with 36 cases in both groups.The control group was treated with conventional western medicine,and the treatment group was treated with Jianpi Tongluo Decoction on the basis of the control group.The course of treatment was 12 weeks.The changes of renal proximal tubule damage indexes,glomerular filtration rate damage indexes,renal function,blood sugar and TCM syndrome scores before and after treatment were compared between the two groups of patients.Result:1.Pre-treatment data of the two groups of patients(gender,age,course of disease,comorbidities,medication status,liver function,blood routine,RBP,α1-MG,NAG,β2-MG,α2-MG,BUN,Scr,24 hUpr,FPG,2hPG,HbA1 c,TCM syndrome scores)have no statistical difference(P>0.05),which is comparable;2.Clinical efficacy of TCM syndromes: the total effective rate of the treatment group is 91.18%,the total effective rate of the control group is 69.7%,and the total effective rate of the treatment group is higher than that of the control group,which is statistically significant(P<0.05);3.TCM single syndrome scores: After treatment,the scores of single TCM syndromes in the two groups were improved(P<0.05).Compared with the control group,it reduced appetite,fatigue,abdominal distension,numbness or numbness after eating.Tingling,pale complexion,On the integral of the syndromes of skin nail fault,edema,and loose stools,the curative effect of the treatment group was better than that of the control group(P<0.05);4.Total scores of TCM syndromes: After treatment,the total scores of TCM syndromes in both groups were improved(P<0.05).Compared with the control group,the therapeutic effect of the treatment group was better than that of the control group(P<0.05);5.Laboratory indicators: after treatment,there was no significant difference in FPG,2hPG,HbA1 c between the two groups(P>0.05);after treatment,there was no significant difference in BUN and RBP between the two groups(P>0.05);after treatment,the treatment group α1-MG,NAG,β2-MG,and α2-MG decreased significantly compared with the control group,and the difference was statistically significant(P<0.05);after treatment,the Scr and 24 hUpr of the treatment group decreased significantly compared with the control group,and the difference was statistically significant(P<0.05).6.Safety indicators: There were no obvious abnormalities in blood routine and liver function before and after treatment,and no obvious adverse reactions occurred during the treatment.In conclusion:1.The treatment of Jianpi Tongluo Decoction combined with western medicine can help improve the clinical symptoms of TCM in patients with spleen deficiency and blood stasis type Ⅲ DKD,and its curative effect has advantages compared with the treatment of western medicine alone.2.Jianpi Tongluo prescription combined with western medicine treatment can reduce serum α1-microglobulin,urine N-acetyl-β-D-glucosaminidase,serum β2-microglobulin,and serum α2-macroglobulin in patients with stage Ⅲ DKD,Serum creatinine,24-hour urine protein quantitative index levels,suggesting that Jianpi Tongluo Decoction can improve renal function and delay the progression of diabetic nephropathy.3.No obvious adverse reactions were seen during the treatment process,indicating that this prescription is safe. |
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