| Objective:To observe the effectiveness and safety of Xingsusan decoction in the treatment of children with post-infection cough syndrome of wind-cold invading lung,and to provide effective and feasible treatment ideas and practical and reliable reference for the future clinical treatment of children with post-infection cough syndrome.Methods:According to the diagnostic criteria of cough after infection in children stipulated by western medicine and the TCM diagnostic criteria of cough cold loving lung syndrome,64 cases of pediatric outpatients in the First Affiliated Hospital of Tianjin University of traditional Chinese medicine from November 2017 to October 2018 were selected and divided into treatment group and control group,with 32 cases in each group,The treatment group was treated with Xingsusan decoction,while the control group was treated with budesonide suspension and ambroxol oral solution by atomization inhalation.One week was taken as a course of treatment in both groups.The scores of main symptoms,secondary symptoms,TCM syndromes and pulmonary signs were recorded before treatment,3 days and 7 days after treatment,Spss22.0 statistical software was used to analyze the clinical trial data.If P<0.05,the difference was statistically significant,and P<0.01,the difference was statistically significant;P>0.05 shows that the difference is not statistically significant,and according to the test results,draw the corresponding conclusion.Results:(1)Main outcome measures: curative effect(1)Comparison of the overall curative effect of the disease: after one course of treatment,the overall curative effect of the two groups: the total effective rate of the treatment group was93.33%,the effective rate was 83.33%;In the control group,the total effective rate was 83.33%,and the effective rate was 50%;By chi square test,the results showed that P>0.05,indicating that the overall efficacy of the two treatment methods to improve the disease is equivalent.(2)Comparison of overall efficacy of TCM syndrome: after one course of treatment,the total effective rate and effective rate of TCM syndrome in the two groups were 96.67% and66.67% respectively;In the control group,the total effective rate was 76.67%,and the effective rate was 30%.By chi square test,the results showed that P<0.05,suggesting that the treatment group to improve the curative effect of TCM syndrome slightly better.(2)Secondary outcome measures: efficacy(1)TCM syndrome score(main symptom + secondary symptom + total score)curative effect: after 3 days of medication,TCM syndrome score of the two groups decreased,and the total score of TCM syndrome of the treatment group was better than that of the control group(P<0.05);After 7 days of medication,the results showed that: the TCM syndrome scores of the two groups were significantly reduced,and the treatment group had obvious advantages in improving the secondary symptoms and the total TCM syndrome scores(P<0.01),indicating that the effect of oral Xingsusan decoction was more significant.(2)Curative effect of main symptom score: after 3 days of treatment,the daytime cough of the two groups were significantly improved,and the curative effect of the treatment group was more prominent,while the improvement of night cough of the two groups was not obvious;There was no significant difference between the two groups(P>0.05);After 7 days of treatment,the main symptoms of the two groups were significantly improved(P<0.01),and the curative effect of the treatment group was outstanding.(3)Analysis of sub symptom scores: after 3 days of treatment,comparison of sub symptom scores between the two groups: the two groups had the same effect in improving the symptoms of expectoration,nasal congestion,chills and hyponatremia(P>0.05);In terms of improving the symptoms of pharyngeal itching,the effect of the control group was significant.The treatment group has more advantages in improving abdominal distension and soft stool.Intra group comparison: in the treatment group,the scores of expectoration,pharyngeal itching and nasal congestion were not significantly reduced,but the scores of chills,abdominal distension,hyponatremia and soft stool were significantly reduced(P<0.05);The control group was not good at improving abdominal distension,chills,lack of appetite,soft stool and other symptoms.After 7 days of treatment,the scores of each symptom were compared: the two groups had significant effect on the treatment of expectoration,nasal congestion and hyponatremia,and there was no significant difference between the two groups(P>0.05),suggesting that the effect of the two groups was the same.In improving the other four symptoms,the treatment group was better than the control group,the difference was statistically significant(P<0.05).Within group comparison,in addition to the control group in the treatment of chills,abdominal distension and soft stool symptoms,the effect was not obvious(P>0.05),other symptom scores compared with before treatment,the difference was statistically significant(P<0.05),and the effect was significant.(4)Pulmonary signs: after 3 days and 7 days of treatment,the results showed that both groups could improve pulmonary signs,and after 3 days of treatment,the curative effect of the two groups was similar(P>0.05);After 7 days of treatment,the curative effect of the control group was better than that of the treatment group(P<0.05).(3)Safety index(1)Before and after treatment,the temperature,heart rate and respiration of the children were in the normal range,and there was no significant difference between before and after treatment(P>0.05);(2)Before and after treatment,the total number of peripheral blood leukocytes and classification indexes of the two groups were compared,and the results showed that P>0.05,suggesting that this experimental study had no significant effect on the Hemogram of children.There were no adverse events or other adverse events in this trial.Conclusion:The treatment group was treated with modified Xingsusan decoction and the control group was treated with budesonide suspension and ambroxol oral solution.The two groups were effective in the treatment of children with post-infectious cough of cold-wind invading lung.The treatment group could effectively improve the symptoms of expectoration,pharyngeal itching and nasal congestion,and had significant effect in the treatment of chills,abdominal distension and soft stool.The control group could also significantly improve the cough Expectoration symptoms,but the treatment of chills,abdominal distension,the effect is not obvious.To sum up,the clinical effect of Xingsusan decoction in the treatment of children with post-infectious cough is obvious. |
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