Clinical Analysis Of 522 Patients With Hepatocellular Carcinoma

Objective:Clinical data of patients diagnosed with hepatocellular carcinoma(HCC)admitted to our hospital from April 2014 to April 2019 were collected to analyze the clinical epidemiological characteristics of the patients,and to discuss the characteristics of HCC in recent years and related clinical issues.Methods:This study used retrospective epidemiological methods to collect clinical data of 522 patients with hepatocellular carcinoma who were hospitalized in our hospital from April 2014 to April 2019,including: gender,age,height,weight,history of smoking and drinking,history of current illness,family history and laboratory tests including blood routine,biochemical indicators,AFP,AFP-L3,AFP-L3%,DCP,Hepatitis B virus markers,coagulation test and imaging results,etc.were recorded by Excel table and analyzed with SPSS26.0 statistical software.Descriptive statistical analysis was conducted on the age distribution,gender distribution,etiological distribution and family history of HCC patients.Logistics regression was used to analyze the risk factors of oncology characteristics,and ROC curve was drawn to analyze the diagnostic efficiency of the triple screening of HCC,and relevant conclusions were obtained.Results:1.A total of 522 patients with HCC were included in this study.Among them,the minimum age of patients is 20 years old,and the maximum age is 86 years old.It is more common between 41-70 years old,and the average age is(57.72 ± 11.24)years old.There were 390 males,accounting for 74.7%,and 132 females,accounting for 25.3%.The male to female ratio was 2.95:1.There were 86 cases with family history of hepatitis B,accounting for 16.5%,and 26 cases with family history of liver cancer,accounting for5.0%.The etiology distribution,384 cases of hepatitis B virus(HBV)infection,accounting for 73.6%,followed by 52 cases of hepatitis C virus(HCV)infection,accounting for 10.0%.2.A univariate analysis of tumor maximum diameter(MTD)related indicators in HCC patients showed that BMI,MVI,distant metastasis,AFP,AST,PLT was significantly correlated with MTD;Multivariate regression analysis showed that AFP,MVI and PLT were independent influencing factors of MTD(OR =2.654(95%CI:1.455-4.838,P = 0.001),3.074(95%CI:1.720-5.496,P < 0.001),1.870(95%CI:1.005-3.481,P = 0.048)).3.A univariate analysis of the influential factors of HCC combined with MVI showed that the tumor number,MTD,distant metastases,AFP,DBIL,TBIL,ALB,AST,ALT was significantly correlated with HCC complicated with MVI;Multivariate analysis showed that tumor number,MTD,AFP,and DBIL were independent influencing factors of MVI(OR= 2.575(95%CI:1.415-4.684,P = 0.002),2.743(95%CI:1.464-5.140,P =0.002)、3.594(95%CI :1.941-6.655,P < 0.001),2.038(95%CI :1.049-3.961,P = 0.036)).4.The sensitivity of AFP-L3%,AFP-L3,DCP,AFP was 54.1%,62.3%,68.9%,70.5%,and the specificity of AFP,AFP-L3,DCP,AFP-L3% was 59.6%,69.2%,73.1%,78.8%,indicating that AFP had the highest sensitivity and AFP-L3% had the highest specificity when detected alone.The sensitivity of AFP,AFP-L3%,DCP triple diagnosis(series)is 47.5% and the specificity is 94.2%.The sensitivity of triple diagnosis(parallel)is 82.0% and the specificity is 44.2%.The results show that the triple diagnosis(series)can improve the diagnosis specificity and triple diagnosis(parallel)can improve sensitivity.Conclusion:1.According to the data analysis of 522 HCC patients included in this study,the incidence of HCC was mainly in the age group above 50 years old,with a male to female ratio of nearly 3:1.Among patients with a family history of liver cancer,HBV infection was the main cause.2.Oncology features of HCC: AFP,MVI and PLT were independent influencing factors of MTD;tumor number,MTD,AFP,and DBIL were independent influencing factors of MVI.3.Diagnostic efficacy of triple test for liver cancer: AFP,AFP-L3% and DCP combined detection can improve the sensitivity and specificity of the diagnosis of hepatocellular carcinoma.