Analysis Of Risk Factors Of Microvascular Invasion In Hepatocellular Carcinoma Caused By Hepatitis B Virus Infection

Objective To explore the risk factors of microvascular invasion(MVI)in patients with HBV-related hepatocellular carcinoma(HCC).Methods The clinical data of patients who underwent hepatectomy in the Department of Hepatobiliary surgery,General Hospital of Ningxia Medical University from January 2015 to December 2019 were collected retrospectively.The patients were divided into groups according to the results of postoperative pathological examination combined with MVI,and the independent risk factors affecting the occurrence of MVI in HBV-related HCC were screened.Results Among the 169 patients with HCC,76 patients were complicated with MVI.Univariate analysis showed that preoperative hepatitis B virus e antigen(HBe Ag)positive,complicated with liver cirrhosis,neutrophil absolute value(NEUT),neutrophil absolute value/ lymphocyte absolute value(NLR),platelet absolute value/lymphocyte absolute value(PLR),γ-glutamyl transpeptidase(GGT),alpha-fetoprotein(AFP),maximum tumor diameter,tumor cell differentiation,invasion of hepatic capsule and satellite focus were the related factors of MVI in HBV-related HCC(P all<0.05).Further logistic regression analysis showed that liver cirrhosis,invasion of hepatic capsule,satellite focus and the increase of GGT and AFP before operation were independent risk factors for MVI in patients with HBV-related HCC(P all<0.05).Conclusion Before operation,the increase of GGT and AFP,liver cirrhosis,invasion of hepatic capsule and satellite focus were closely related to the occurrence of MVI in patients with HBV-related HCC.