| Objective: To observe the clinical effect of photodynamic therapy on type II rose acne,compare the clinical effect of photodynamic therapy with routine doxycycline in the treatment of type II rose acne,and further explore the effect of photodynamic therapy on the serum LL-37 expression level of type II rose acne patients.Methods: From November 2019 to October 2020,60 patients with type II rosacea in the Affiliated Hospital of Qinghai University were randomly divided into the treatment group and the control group.30 patients in the treatment group were given photodynamic therapy once every two weeks for three times;30 cases in the control group were given doxycycline hydrochloride tablets orally,once a day,0.1g each time for 6 weeks.Before and after treatment,Extraction of 2 m1 of peripheral venous blood from all subjects,Detection of serum LL-37 expression level.Results: Total efficiency after photodynamic therapy was 93.33%,higher than83.33% of doxycyclin therapy in the control group,with significant differences between the two groups(P< 0.05).There was no significant difference in serum LL-37 expression between the two groups before treatment(P>0.05).The level of serum LL-37 expression in both groups decreased after treatment(p<0.001).Compared with doxycycline treatment,photodynamic therapy significantly decreased the expression of LL-37 in serum(P < 0.05).Conclusions: Photodynamic therapy is effective in the treatment of type II rose acne,and is more effective than doxycycline.Photodynamic therapy can inhibit the expression of serum LL-37 in the treatment of type II rose acne. |
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