| Purpose:Observe the TCM syndrome scores,total 24-hour urine protein(U-TP),urine protein(PRO),urinary occult blood(BLD)and urine in the treatment of spleen and kidney qi deficiency purpura nephritis(HSPN)patients with Bu shen Jian pi She xue Decoction Changes in the red blood cell(RBC)count of sediment,to evaluate its clinical effectiveness and safety,and to provide a theoretical basis for its wide application in clinical practice.Study method:Selected 60 patients who were admitted to the nephrology clinic and inpatient department of Gansu Central Hospital between January 2020 and December 2020,and who met the criteria for inclusion and exclusion of spleen and renal gas vanity nephritis,were divided into control groups according to the principle of random control(Basic therapy plus satan capsules)and treatment group(control group plus renal spleen and blood soup),after 8 weeks of treatment,the two groups of patients before and after treatment of TCM certificate points,24 h total urinary protein(U-TP),urine protein(PRO),Changes in urine latent blood(BLD),urine scum red blood cell(RBC)count and safety indicators,and statistical analysis and summary of relevant data.Results:(1)Comparison of curative effect of TCM syndromes: The effective rate of the treatment group(90%)is higher than that of the control group(76.67%).The comparison between the two is P?0.05,which is statistically significant.(2)Comparison of TCM symptom scores: the scores of TCM symptoms(purpura of the skin,backache,fatigue,fatigue,poor appetite,irregular bowel movements,increased nocturia,poor complexion,fullness of the stomach)and TCM syndromes of the two groups before treatment The total scores of candidates are all comparable(P>0.05).After treatment,the total scores of TCM syndromes of the two groups of patients decreased(P?0.05),and the treatment group was significantly better than the control group(P?0.05).After treatment,the scores of various TCM symptoms of the two groups decreased(P?0.05).The treatment group was significantly better than the control group in terms of skin purpura,lumbar and spinal soreness,fatigue,poor appetite and appetite,irregular bowel movements,and nocturia.(P?0.05),but after treatment,there was no significant difference between the two groups of patients’ complexion and abdominal distension(P>0.05).(3)Comparison of laboratory indicators: The comparison of total urine protein,urine protein,urine occult blood and urine sediment red blood cell counts between the two groups at 24 h before treatment was not statistically significant(P>0.05).After treatment,the total urine protein,urine protein,urine occult blood and urine sediment red blood cell counts of the two groups were lower than before(P ?0.05),and the treatment group was better than the control group(P?0.05).And the effective rate of the treatment group(86.67%)was higher than that of the control group(73.33%).The comparison between the two groups was P?0.05,which was statistically significant.(4)Safety analysis: There were no obvious abnormalities in the safety indicators of the two groups of patients during the treatment process,and no adverse reactions occurred.Conclusion:(1)Bu shen Jian pi She xue Decoction can reduce the 24-hour total urine protein,urine protein,urine occult blood and urine sediment red blood cell count in patients with HenochSch9 nlein purpura(spleen and kidney qi deficiency).(2)Bu shen Jian pi She xue Decoction can improve skin purpura,lumbar spine weakness,fatigue,lack of food and appetite,irregular bowel movements,increased nocturia,poor complexion,and epigastric in patients with Henoch-Sch9 nlein purpura(spleen and kidney qi deficiency).Symptoms of abdominal distension and good safety. |
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