The Expression And Significance Of CD24 And Siglec-10 In Epithelial Ovarian Cancer

Objective To analyze the expression of CD24 and Siglec-10 in different ovarian tissues,and to explore the expression and significance of CD24 and Siglec-10 in epithelial ovarian cancer.Methods The expression of CD24 and Siglec-10 were detected by immunohistochemistry(SP),and the expression and characteristics of the two in different ovarian tissues were analyzed,and the relationship between CD24,Siglec-10 and different pathological parameters of epithelial ovarian cancer was discussed.Analyze the correlation between the expression levels of CD24 and Siglec-10 in epithelial ovarian cancer.Combined with the follow-up results to explore its relationship with the occurrence and development,invasion and metastasis,relapse and drug resistance of epithelial ovarian cancer.Results CD24 and Siglec-10 are not expressed in normal ovarian tissues,but the expression levels of CD24 and Siglec-10 gradually increased with the malignancy of ovarian tumors;The expression level of CD24 between any two groups of ovarian tumor tissues and the overall comparison between the three groups of ovarian tumor tissues was statistically significant(P<0.05).The expression level of Siglec-10 was compared between any two groups of ovarian tumor tissues and between the three groups of ovarian tumor tissues,and the differences were all statistical significance(P<0.05);The high expression levels of CD24 and Siglec-10 in epithelial ovarian cancer have a significant correlation(rs=0.500,P<0.001);The expression levels of CD24 and Siglec-10 are closely related to the FIGO staging,lymph node metastasis,omental metastasis,pelvic and abdominal implantation,recurrence and drug resistance of patients with epithelial ovarian cancer,and the difference was statistically significant(P<0.05).Conclusion 1.The high expression of CD24 and Siglec-10 is related to the malignant proliferation of ovarian tumor tissue.2.The high expression of CD24 and Siglec-10 is related to the invasion,metastasis and prognosis of EOC.3.CD24-Siglec-10 is expected to become a new immune detection point,providing more value and possibilities for EOC patients in immunotherapy.