The Clinical Efficacy Of Ganluyin In The Treatment Of CKD1-2 CGN Patients With Deficiency Of Both Qi And Yin And Damp-heat Syndrome Based On The Method Of Syndrome Differentiation And The Observation Of C3 And C4

ObjectiveThis study explored the clinical efficacy of Ganluyin in the treatment of CGN patients with deficiency of both qi and yin and damp-heat syndrome based on the syndrome differentiation method and its influence on complement C3 and C4.The clinical symptoms and urine routine,renal function,complement C3,and complement C4 were observed before and after treatment And other indicators to clarify the relevant mechanism of action.MethodsFrom November 2019 to November 2020,72 patients with chronic glomerulonephritis of qi and yin deficiency and damp-heat type who were in the outpatient department and nephrology ward of the People’s Hospital of Fujian University of Traditional Chinese Medicine who met the inclusion criteria were collected from November 2019 to November2020.Random number method was used.Randomly divided into 36 cases in the experimental group and 36 cases in the control group.On the basis of conventional treatment,the two groups were treated with valsartan,the experimental group was treated with Ganluyin plus flavor,and the course of treatment was 4 weeks.During the treatment,two patients were excluded from the experimental group and the control group due to non-compliance with the doctor’s instructions and loss to follow-up.Detect urine red blood cell count(ERY),24-hour urine protein quantification(24h Upro),blood creatinine(Scr),urea nitrogen(BUN),glomerular filtration rate(eGFR),immunological indicators(C3、C4)before and after treatment.And the changes of TCM syndrome scores,and make relevant statistical analysis.Results(1)Two groups of patients meeting the inclusion criteria,general information(sex,age,course of disease,etc.),observation indicators(ERY,24h Upro,Scr,BUN,eGFR,complement C3,complement C4),TCM syndrome scores,The differences in safety indicators were not statistically significant(P>0.05),and they were comparable.(2)Comparing the two groups after treatment,ERY,24h Upro and Scr of the test group decreased before and after treatment,eGFR and C3 increased(P<0.05),and there was no significant difference in BUN and C4(P>0.05);Before and after treatment,ERY and24h Upro decreased,C3 increased(P<0.05),and there was no significant difference in BUN,Scr,eGFR,C4(P>0.05).The difference between the two groups in the ERY,24h Upro,and C3 groups was statistically significant(P<0.05),and the test group was better than the control group;while the two groups had no statistically significant differences in the Scr,BUN,eGFR,and C4 groups(P>0.05).(3)The clinical symptoms of the two groups were improved after treatment,and the scores of TCM syndromes decreased.The effective rate of TCM syndromes in the experimental group was 88.24%;the effective rate of TCM syndromes in the control group was 64.71%.Comparison between the two groups,The difference is statistically significant(P<0.05),and the test group is better than the control group.(4)Comprehensive clinical efficacy after treatment,the effective rate of the experimental group was 85.29%,and the effective rate of the control group was 70.59%.The difference between the two groups was statistically significant(P<0.05),and the experimental group was better than the control group.Conclusion:(1)The therapeutic effect of Ganluyin on the clinical symptoms of CGN patients with deficiency of both qi and yin and damp-heat syndrome is better than that of western medicine alone based on the differentiation of syndromes of right and evil.(2)Ganluyin-modified and conventional western medicine treatments can effectively reduce ERY and 24h Upro,both can stabilize BUN,Ganluyin-modified can reduce Scr and increase eGFR;and the use of Ganluyin-modified treatment can reduce the levels of ERY and 24h Upro in CGN On the other hand,it is better than pure western medicine treatment.(3)The use of Ganluyin plus on the basis of syndrome differentiation method to increase the level of complement C3 was more significant than that of the control group.Both treatment methods can effectively regulate the immune function of patients.(4)It shows that the addition of Ganluyin can significantly improve the clinical symptoms and physical and chemical indicators of CGN patients with deficiency of both qi and yin and damp-heat syndrome,regulate the immune function state,and achieve the effect of strengthening the body and eliminating evil.