| Objective The aim of this study is to investigate the clinical efficacy of the self-formulated Yigi Huoxue Huatan Recipe in the treatment of wind-phlegm obstructed acute cerebral infarction(ACI)and its influence on collateral circulation,through theoretical research,clinical efficacy observation and safety observation,and to provide a basis for the treatment of wind-phlegm obstructed acute cerebral infarction(ACI).Methods Patients who met the case selection criteria of this study were randomly divided into 30 cases in the Traditional Chinese medicine(TCM)group and 30 cases in the control group.The control group was given conventional basic treatment: general management of the acute phase,anti-platelet aggregation,improvement of cerebral metabolism,lipid regulation,and treatment of comorbidities and complications.The TCM group was given conventional basic treatment and the formula of Yigi Huoxue Huatan(composed of Astragalus,arisaema cum bile,Rhizoma pinellinae praeparata,Radix Codonopsis,Tao Ren,Safflower,Angelicae Sinensis,Salviae Miltiorrhizae,Rhizoma gastrodiae and Centipede),100ml/bag,taken warm after meals,3 times a day.The treatment course was 14 ± 2 days,and the changes in the levels of homocysteine(Hcy),neuron-specific enolase(NSE),National Institutes of Health Stroke Scale(NIHSS)score,TCM symptoms score,ability to care for oneself(ADL)score and TCD assessment of cerebral collateral circulation opening were compared before and after treatment in the two groups.Results 1.There is no statistical difference between the two groups at baseline(P > 0.05).2.In terms of effectiveness of clinical treatments the NIHSS scores of the two groups were compared,with a total efficiency of 93.3%for the TCM group and 86.7% for the control group,with statistical differences(P <0.05).The therapeutic efficacy of TCM evidence of the points of the two group was assessed,the total effective rate of the TCM group was 96.7% and the total effective rate of the control group was 83.3%,which was statistically different(P < 0.05).3.When the post-treatment NIHSS scores were compared with each other,the decrease in the TCM group was greater than that of the control group,with statistical differences(P < 0.05).4.When comparing the TCM symptoms score after treatment,the decrease in the TCM group was greater than that of the control group,with a statistical difference(P < 0.05).5.When comparing the collateral circulation after treatment,the improvement rate of the TCM group was higher than that of the control group,with statistical differences(P < 0.05).6.When comparing the Hcy levels after treatment,the decrease in the TCM group was greater than that in the control group,with a statistical difference(P < 0.05).7.When comparing NSE levels after therapy,the decrease was more pronounced in the TCM group,but there was no statistical difference compared to the control group(P > 0.05).8.When comparing the ADL scores after treatment,the TCM group improved more than the control group,with a statistical difference(P < 0.05).9.Safety observation,no adverse reactions and drug safety damage were observed throughout the treatment process in both groups,safety evaluation grade 1.Conclusion On the basis of the conventional Western medicine treatment,the self-formulated of Yiqi Huoxue Huatan can be effectively applied to ACI patients with wind-phlegm blockage,which can effectively improve cerebral collateral circulation,reduce Hcy level,lower the degree of neurological deficiency and TCM symptoms score,and increase ADL value.Compared with Western basic therapy and without toxic side effects,it can be used as an adjuvant treatment for ACI patients with wind-phlegm blockage. |
PDF Full Text Request