Clinical Observation Of Self-made Quban Recipe Combined With Oral Tranexamic Acid For Oral Treatment Of Chloasma

Objective: To observe the clinical efficacy and safety of Quban Recipe combined with oral tranexamic acid in the treatment of chloasma,and provide a new method for the treatment of chloasma with traditional Chinese medicine and modern technology.Methods: A total of 60 chloasma patients who were treated in the First Dermatology Clinic of Hebei Provincial Hospital of Traditional Chinese Medicine and the Dermatology Clinic of Hebei Academy of Chinese Medical Sciences in May to August,2019.A total of 60 cases were recorded.Basic information was recorded and relevant indicators were selected to evaluate the treatment.effect.The patients were divided into two groups by random number method,and the control group was given tranexamic acid 500 mg Qd orally,a broad-spectrum physical sunscreen,and a moisturizing mask.The experimental group applied homemade Quban Fang externally on the original basis and transdermally administered by iontophoresis twice a week.The observation period was 3 months,and the effective rates after 4 weeks,8weeks,and 12 weeks were summarized.The advantages and disadvantages of this method were evaluated by comparing the MASI score before and after treatment,the changes in the absolute value of the brown zone under VISIA,and the adverse reactions.Result:1.General results: The age of onset of chloasma patients is between 36 and 40 years,and the onset time is concentrated within 3-5 years.2.In the chloasma severity score(MASI)score,the experimental group and the control group were not statistically significant at weeks 0 and 4 after treatment,and there were statistically significant differences at weeks 8 and 12(P <0.05)3.The absolute value of the VISIA brown zone in the two groups after 3months of treatment was statistically tested(P <0.001),there is a statistical difference4.There was no statistical difference in the total effective rate between the 4th week and the 8th week in the experimental group and the control group;P = 0.024 〈0.05 at the 12 th week.The experimental group had a statistical difference compared with the tranexamic acid group alone.5.No significant adverse reactions occurred during the treatment of the two groups of patients.Conclusion:The introduction of self-made Quban prescription combined with oral administration of tranexamic acid can increase the local drug concentration,promote the transdermal absorption of active ingredients in the form of ions,and improve the therapeutic effect of chloasma.Despite the slow onset,there is no obvious skin irritation,the patient’s acceptance is high,and the clinical application value is high...