Clinical Observation On The Chuzhilishi Decoction In Treating Facial Seborrheic Dermatitis

Objective: By observing the changes of symptoms score(erythema,scales,pruritus,greasy)of patients before and after treatment,and compare with the clinical efficacy of Chuzhilishi Decoction and Vitamin capsule in the treatment of facial seborrheic dermatitis,to observe the differences in adverse reactions,recurrence rate and safety between the two treatment schemes,anticipated to provide clinical experience basis for the treatment of facial seborrheic dermatitis with Chuzhilishi Decoction.Methods: 90 patients who conformity with the diagnostic criteria of both traditional Chinese medicine and Western medicine symptoms of facial seborrheic dermatitis were selected as study subjects.All cases were from the dermatological Department of Chinese Medicine Hospital of Hebei Province.By following the randomized controlled trial methodology,they were divided into treatment group and control group,45 patients in the treatment group and 45 patients in the control group.The treatment group was given oral administration of Chuzhilishi Decoction,take one dose daily,and take warm medicine twice in the morning and evening.The control group was given oral administered with vitamin ester capsules,50 mg each time,twice a day.At the same time,both groups were administered topically with pimecrolimus cream twice a day.Record the symptoms(skin lesion area,erythema,scales,pruritus,greasy)of the two groups before treatment and after4 weeks of treatment to compare the clinical efficacy,and observed the adverse reactions occurred during treatment and the recurrence after treatment.Result: 1.Comparison of general data: After exfoliation and removal of the cases,85 complete cases were selected,43 cases in the treatment group and 42 cases in the control group.After statistical analysis of gender,age,course of disease and symptom score before treatment,the difference was not statistically significant.(P>0.05),which was comparable.2.Comparison of clinical efficacy: After 4 weeks of treatment,among the43 patients in the treatment group,10 patients were cured,21 patients were markedly effective,7 patients were effective and 5 patients were ineffective,the total effective rate was 88.37%.Among the 42 patients in the control group,4 patients was cured,12 patients were markedly effective,14 patients were effective and 12 patients were ineffective,with a total effective rate of 71.42%.After statistical analysis(rank sum test),the difference was statistically significant(P<0.05),indicating that the effective rate of the treatment group was higher than the control group.3.Comparison of adverse reactions: During treatment,two patients in the treatment group had adverse reactions,and 10 patients in the control group had adverse reactions.After statistical analysis(rank sum test),showed that the difference was statistically significant(P<0.05),indicating that the incidence of adverse reactions in the treatment group was lower than that in the control group.4.One month after treatment,the recovered patients and the effective patients were random interviewed;there were 4 recurrences among 31 patients in the treatment group and 7 recurrences among 16 patients in the control group.After statistical analysis(chi-square test),the difference was statistically significant(P<0.05),indicating that the recurrence rate in the treatment group was lower than that in the control group.5.During the treatment,there were no serious adverse reactions in both groups,which indicated that the two treatment regimens were relatively safe.Conclusion:The efficacy of Chuzhilishi Decoction in the treatment of facial seborrheic dermatitis is better than that of Vitamide ester capsule,the incidence of adverse reactions and recurrence rates are relatively low,so it can be effectively applied in clinical practice.