| Purpose:To evaluate the feasibility of global brain volumetric and relaxometry in differentiating Parkinson’s disease patients from healthy controls using the synthetic Magnetic Resonance Imaging(MRI)technique.Method:Twenty-eight PD patients(age:67±11 years)and the same number of healthy controls(age:68±8 years)were enrolled in this study.All participants underwent synthetic MRI(MAGnetic resonance Imaging Compilation,MAGiC)acquisition on a 3T MRI scanner(Signa Pioneer,GE Healthcare).Volumetric characteristics including white matter volume(WMV),gray matter volume(GMV),cerebral spinal fluid volume(CSFV),myelin volume(MYV),brain parenchymal volume(BPV),intracranial volume(ICV),white matter fraction(WMF=WMV/BPV),gray matter fraction(GMF=GMV/BPV),myelin fraction(MYF=MYV/BPV)and cerebral spinal fluid fraction(CSFF=CSF/ICV)were acquired.The average relaxometric characteristics including T1,T2 and proton density(PrD)values in WM,GM and CSF were calculated from voxels with partial volume exceeding 95%of the corresponding tissue.Independent-samples t-test was used to assess the difference of the age,volumetric and relaxometric characteristics between two groups.Chi-square test was used to assess the gender difference between two groups.Results:No difference was observed in age(P=0.587)and gender(P=0.181)between these two groups.For volumetry,WMV,WMF,MYV and MYF were significantly higher while GMF were significantly lower in PD patients.No difference was observed in GMV,BPV,ICV,CSFV and CSFF.For relaxometry,GM T1 value,WM T1 value were significantly higher while CSF PrD value were significantly lower in PD patients.No difference was observed in CSF T1 value,CSF T2 value,WM T2 value,and WM PrD value.Conclusion:Volumetry and relaxometry simultaneously obtained from synthetic MRI may have potential to be used as quantitative markers for clinic to differentiate Parkinson’s disease patients among the healthy. |
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