Quantitative Imaging Study Of SyMRI Combined With ASL Imaging Of Brain Regions Of Interest In Parkinson’s Patients

Objective: To explore the diagnostic value of brain gray matter nuclei T2 values and CBF values in patients with early and middle and late Parkinson’s disease(PD)by synthetic magnetic resonance imaging(Sy MRI)and arterial spin labeling(ASL)techniques.Methods:In this study,30 patients with clinically confirmed PD(PD group)and 21 healthy controls(HC group)were collected,the T2 and CBF values of each nucleus in the basal ganglia and the thalamus were measured separately,and the differences between the two groups were compared.The T2 and CBF values of the nuclei with differences were analyzed by ROC curves to determine the diagnostic efficacy.The PD group was then divided into early PD group(PD-1 group)and middle and late PD group(PD-2 group)according to Hoenh-Yahr staging,,and the T2 values and CBF values of the nuclei were compared differently between the groups.Spearman correlation analysis was further used to investigate the relationship between the amount of iron deposition,cerebral perfusion and clinical grading of PD,respectively.Results:The comparison revealed that there were statistical differences in the T2 values of substantia nigra,red nucleus and putanmen in the PD and HC groups,and differences in the CBF values of substantia nigra,thalamus,putanmen and pallidum,with the pallidum CBF values having better diagnostic efficacy.The PD-1 group had no difference in substantia nigra and red nucleus T2 values from the HC group,and the rest of the groups were statistically different from each other.The T2 values of the PD-1 and PD-2 groups in the putanmen differed from those of the HC group,respectively,while the pallidum,thalamus and caudate nucleus were not statistically different between groups.Substantia nigra red nucleus T2 values are significantly correlated with clinical grading of Parkinson’s disease.The substantia nigra,thalamus,putanmen and pallidum CBF values were statistically different between groups,with substantia nigra,putanmen and pallidum PD-1groups being statistically different from the control group.In contrast,there was no difference in CBF values between PD-1 and PD-2 groups.The CBF values of thalmus correlated with clinical grading of Parkinson’s disease.Conclusion:The presence of iron deposition as well as abnormal cerebral perfusion in some nuclei of PD patients and the correlation of some indicators with H-Y classification suggest that cerebral perfusion and abnormal iron metabolism are involved in the onset and development of Parkinson’s and are expected to be potential quantitative imaging indicators for PD.