Efficacy And Safety Evaluation Of Fractionated 1064-nm Nd:YAG Picosecond Laser With Different Energy Density In The Treatment Of Facial Photoaging

Background:As photoaging has become a major aesthetic concern,it has received increasing attention.The fractionated 1064-nm Nd:YAG picosecond laser is a new noninvasive rejuvenation technology.Object:To compare the efficacy and safety of fractionated 1064-nm Nd:YAG picosecond laser with different energy on facial photoaging.Method:25 subjects with moderate to severe photoaging were enrolled in a prospective evaluator-blinded,randamized,and split-face trial.Both sides of the face received laser treatment with high and low energy density 3 times respectively.Blinded evaluation of baseline and one-month follow-up visit was performed by three independent dermatologists with a 5-point Global Sore for Photoaging(GSP),6/8-point Asian Photographic Scale(APS)and Global Aesthetic Improvement Score(GAIS).Visual Analogue Scale(VAS)was adopted to measure the feeling of pain after each treatment.Adverse events and discomfort associated with the treatment were also assessed.Result:23 subjects completed all treatments and follow-up.At the 4-week follow-up after 3 treatments,the GSP of the subjects on the low and the high energy density side decreased from 3.07±0.63 to 2.86±0.60 and 2.75±0.63,respectively(P<0.05);the difference of the efficacy between the two groups was significant(P<0.05).The APS wrinkle scores of subjects on the low and the high energy density side decreased from 3.32±0.99 and 3.32±0.99 to 3.14±0.97 and 3.03±0.97,respectively(P<0.05),and the difference between the two groups was significant(P<0.05);the APS dyspigmentation score decreased from 2.48±0.99 and 2.41±1.02 to 2.22± 1.0 and 2.13±1.0,respectively(P<0.05),there was no significant difference between the two groups(P>0.05).The level of pain of the low energy density side was lower than that of the high energy density side(P<0.05),and the downtime was shorter than that of the counterpart.Conclusion:Both 1064-nm Nd:YAG picosecond fractional laser with low and high energy density can effectively and safely improve facial photoaging.Fractionated 1064-nm Nd:YAG picosecond laser with high energy density performed better than its counterpart in skin rejuvenation,though their effect on improving the dyspigmentation was comparable.Fractionated 1064-nm Nd:YAG picosecond laser with low energy density was less painful and had a shorter downtime than its counterpart.