Study On The Theory Of Spasmodic Syncope And The Regularity Of Syndrome Differentiation And Treatment Of Spasmodic Syncope In Febrile Diseases

Since COVID-19 became rampant,Chinese medicine has played an important role in medical treatment.Traditional Chinese medicine scholars widely believe that COVID-19 is an epidemic acute exogenous fever caused by the unhealthy environmental influences of "pestilence" and belongs to the category of "pestilence".During the most severe critical phase of COVID-19,patients often rapidly develop nervous system dysfunction such as febrile spasmodic syncope and septic shock.How to efficiently distinguish and treat the acute disease in critical period is the key to the outcome of exogenous fever and also the difficulty in treatment.spasmodic syncope is one of the most common TCM emergencies in clinical practice.It often appears in the critical stage of the course of febrile disease.It can be seen as an independent symptom in other diseases,or as a single major disease.Ancient books are the main carrier of the academic theory and clinical diagnosis and treatment experience of ancient doctors.Through the exploration and mining of the effective knowledge in ancient books,we can explore the new discovery on the treatment of spasmodic syncope,and provide reference for the clinical diagnosis and treatment of neurological diseases related to modern medicine.ObjectiveSort out the academic source of spasmodic syncope and explain the connotation of spasmodic syncope.Summarize the etiology and treatment of spasmodic syncope in the process of febrile disease.Mining and analyzing the drug rules can promote the effective information in ancient books to better serve the clinical practice,and provide reference for the clinical diagnosis and treatment of modern medical-related neurological diseases.Methods and Contents(1)Origin and development research of spasmodic syncopeUse the literature analysis method to comb and discuss the academic source flow of spasmodic syncope.From the interpretation of "spasm" and "syncope",combine with the understanding of "spasm" and "syncope" symptoms and etiology and pathogenesis to discuss the emergence and treatment of the name of spasmodic syncope,and lay the documentary foundation for the next research of spasmodic syncope.(2)Contents of spasmodic syncope and spasmodic syncope in febrile diseasesUsing the induction and interpretation method,expand spasmodic syncope from the symptoms to the connotation of the disease,and clarify the disease name,symptoms and etiology of spasmodic syncope,which is the theoretical premise of spasmodic syncope.(3)Cause and syndrome differentiation and treatment of spasmodic syncope in febrile disease.By using the method of literature analysis,it is divided into three parts:febrile diseases of warm heat,febrile diseases of damp heat,and febrile diseases of poison and pestilence.Investigate the etiology and treatment characteristics of spasmodic syncope in febrile disease.(4)Drug rule of spasmodic syncope in febrile diseaseBy using the method of data mining,the prescription data of febrile disease spasmodic syncope were divided into three categories according to febrile diseases of warm heat,febrile diseases of damp heat,and febrile diseases of poison and pestilence.Mathematical statistics(frequency,rate),correlation analysis and cluster analysis were carried out to summarize and analyze the medication rules of febrile disease spasmodic syncope.Results(1)By combing the historical origin of spasmodic syncope,it is found that before the Qing Dynasty,"spasm" and "syncope" were regarded as two different syndromes.Doctors in the Qin and Han Dynasties had a preliminary understanding of "spasm"and "syncope" and put forward the theory that spasm was caused by exogenous factors,and believed that syncope was the reverse disorder of qi mechanism caused by the imbalance between Yin and Yang.In Jin,Sui and Tang dynasties,the treatment of external spasmodic syndrome was supplemented,and treatments of various syncope diseases were added on the basis of Internal Canon of Medicine,and the system of "spasm" and "syncope" treatment was initially formed.In the Jin and Yuan dynasties,the physicians had great achievements in etiology and pathogenesis,and put forward the view that spasm was caused by external evil and internal injury together,and systematically summarized various types of syncope diseases,which greatly enriched the etiology and pathogenesis theories of "spasm"and "syncope".On this basis,later generations of doctors began and developed the study of spasmodic syncope(2)Discuss the connotation of spasmodic syncope and spasmodic syncope in febrile disease,covering the symptoms of stiff neck,spasmodic syncope,clonic syndrome and the symptoms of dizziness,confusion,fainting and other symptoms.There are many causes,typhoid,internal injuries,but the spasmodic syncope in febrile disease is particularly common.So it refers to the spasmodic syncope that occurs in the process of febrile disease.(3)Exploring spasmodic syncope in febrile disease,the main pathological factors are wind,humidity,heat evil,summer-heat evil and secondary pathological products such as phlegm dampness and blood stasis.The main diseases are febrile evil subsidence,thick and close phlegm,Yangming fever,heat blood stasis.(4)According to the types of febrile disease,it is divided into warm diseases,damp heat diseases and poison and pestilence diseases.The spasmodic syncope in febrile diseases mainly include heat injury of Qi and Yin,evil in heart and liver,phlegm heat closed tips,hot blood stasis,Yangming heat,Qi and Yin injuries.The spasmodic syncope in damp heat febrile diseases are mainly damp and heat brewing phlegm,damp and heat stuffy feeling,stomach fever fluid exhaustion,and wet fire internal closure.The spasmodic syncope in febrile disease of poison and pestilence is mainly filled by fire virus,damp heat pestilence virus and dry heat pestilence virus.In the treatment,we should correct and dispel evil,early prevention and control,attack and dispel evil,reconcile Yin and Yang,urgent evidence urgent decision and care for Yin liquid.The 10 traditional Chinese medicines with high frequency in febrile diseases are rhinoceros horn,licorice,dried rehamnnia root,antelope horn,radix scrophulariaen,gypsum,cinnabar,musk,forsythia and ophiopogon respectively.Common drug pairs for treatment are:musk-cinnabar,cinnabar-bezoar,musk-bezoar,baicalin-gardenia,baicalin-coptis chinensis,cinnabar-borneol.Through clustering analysis,it is divided into six types of drugs,such as clearing heat and nourishing yin,inducing resuscitation,clearing away heat and relieving diarrhea,nourishing yin and suppressing hyperactive yang.The 10 traditional Chinese medicines with higher frequency in damp heat febrile diseases are rhinoceros horn,cinnabar,forsythia,dried rehamnnia root,antelope horn,ginseng,musk,talc,coptis chinensis and licorice.The treatment of common drug pairs are:rhinoceros horn-radix scrophulariae,rhinoceros horn-antelope horn,musk-cinnabar,forsythia-rhizoma acori graminei,rhinoceros horn-rhizoma acori graminei,forsythia-honeysuckle,etc.Through clustering analysis,it is divided into four types of drugs,including opening orifices and soothing liver,clearing heat for calming endogenous wind,clearing away heat and relieving diarrhea,clearing away heat and eliminating dampness.The 10 traditional Chinese medicines with high frequency in the poison and pestilence febrile diseases are rhinoceros horn,dried rehamnnia root,cinnabar,musk,antelope horn,white peony,licorice,borneol,realgar and ginseng.The common drug pairs for treatment are:musk-cinnabar,musk-borneol,cinnabar-borneol,musk-realgar,antelope horn-gypsum,etc.Through clustering analysis,it is divided into four kinds of drugs,including repel foulness and open the orifices,clearing heat for calming endogenous wind,combination of bitter cold and bitter warm and clearing heat and nourishing yin.Conclusion(1)The understanding of "spasm" and "syncope" by successive doctors is the theoretical basis of spasmodic syncope put forward by febrile doctors in later generations.In addition,by exploring the connotation of spasmodic syncope,the relevant symptoms of spasmodic syncope were sorted out,solved the incomplete and unclear connotation caused by irregular symptom names and unclear symptoms,and put forward the possibility of treating spasmodic syncope as a disease.(2)The treatment of febrile spasmodic syncope is mainly based on clearing away heat and nourishing yin,opening orifices and calming wind,but each has its own characteristics.From the efficacy point of view,the main drugs used for febrile spasmodic syncope are heat clearing,yin nourishing,resuscitation and wind calming,and the main drugs are eliminating heat evil and taking care of yin protecting liquid.The main drugs for spasmodic syncope of damp heat disease are clearing away heat and resuscitation,calming wind,removing dampness and soothing liver and regulating qi.The main drugs for poison and pestilence febrile diseases are clearing away heat and nourishing yin,dispelling filth and detoxifying,supplementing qi and strengthening the body.Because spasmodic syncope is common in the extreme stage of febrile disease,the pathogenesis and treatment of febrile disease are different.According to different types of disease and syndrome,the corresponding treatment principles and methods are put forward.Through the data mining method,the results of the analysis of the treatment prescriptions further corroborate the relevant conclusions in the theoretical research,and present the compatibility and treatment rules of spasmodic syncope drugs in the process of different types of febrile diseases in a more intuitive and detailed way,so as to provide reference for clinic.