| ObjectiveThis study carried out a clinical randomized controlled trial to observe the improvement of Eczema area and severity index score(EASI)and visual analogue scale(VAS)in the treatment of chronic eczema of spleen deficiency and dampness accumulation type with filiform-fire needle combined with moxibustion,and compared with conventional western medicine treatment,providing a set of effective,less side effects and more acceptable TCM external treatment measures and programs for patients.At the same time,it can provide more effective clinical evidence for TCM External Treatment of eczema,and provide the basis for the mechanism research of TCM treatment of eczema in the future.MethodsThe diagnostic criteria of traditional Chinese medicine refer to the Chinese medicine industry standard of the people’s Republic of China(2017 Edition).The diagnostic criteria of Western medicine refer to the Chinese guidelines for the diagnosis and treatment of atopic dermatitis published by Chinese Journal of dermatology in 2014.The patients who met the diagnostic criteria of traditional Chinese and Western medicine and did not take drugs related to the treatment of the disease within 30 days before treatment,and did not use external drugs related to the treatment of the disease within 7 days were included in this study.First,64 opaque envelopes are numbered.Then using spss25.0 software to generate 64 random numbers,each random number corresponding to a number,and visual box processing,according to the ratio of 1:1,each random number corresponding to the treatment group or the control group,32 cases in each group.Finally,64 treatment cards were made,and the cards marked with millifire needle combined with moxibustion and conventional western medicine treatment were put into the envelopes of the treatment group and the control group respectively,and 64 random envelopes were obtained.Then the sealed envelopes were arranged in the order of number and handed over to a dermatologist who did not participate in this study.After the start of the study,the patients received the envelopes in order of participating in the study,and strictly followed the treatment plan indicated by the random distribution card in the envelope for standardized treatment.The treatment group was treated with filiform-fire needle combined with moxibustion.The filiform needle was performed from the center of the lesion to the surrounding area.The needling was performed twice in a row,and the needling distance was 1cm until the whole lesion was covered.The prick depth should be controlled at 3mm.Quchi point,Zusanli point,Pishu point,yinlingquan point and 1-2 places with severe skin lesions were selected for mild moxibustion.Moxibustion on each part for 10 minutes.The above treatment was carried out twice a week,2 weeks as a course of treatment,2 days off after the end of one course,a total of 2 courses.The control group took cetirizine hydrochloride tablets 10mg orally every night,combined with mometasone furoate cream,applied to the skin lesions once a day.Before application,the skin should be kept clean and evenly applied from less to more.2 weeks as a course of treatment,a total of 2 courses.Eczema area and severity index score(EASI)and visual analogue scale(VAS)were recorded before and after treatment.After the course of treatment,the curative effect was evaluated according to the curative effect evaluation standard.Finally,data were collected for statistical analysis.Results1.Basic data:there was no significant difference in gender,age and course of disease between the control group and the treatment group(P>0.05),so the baseline level of the two groups was balanced and comparable.2.Easi score and VAS score before treatment:(1)By Independent-sample test,there was no significant difference in EASI total score and symptom score between the two groups and comparable before treatment(P>0.05).(2)By Independent-sample test,there was no significant difference in VAS score between the two groups and comparable before treatment(P>0.05).3.Curative effect comparison:(1)Comparison of skin lesions before and after treatment in two groups①By paired test,the difference of total score and each score of EASI of the treatment group before and after treatment were statistically significant(P<0.05).②By paired test,the difference of total score and each score of EASI of the control group before and after treatment were statistically significant(P<0.05).(2)Comparison of skin lesions between the two groups after treatment①By Independent sample test,the difference of total score and each score after treatment between the two groups was statistically significant(P<0.05).②By Independent sample test,the difference of score variances of EASI score between the two groups before and after treatment was statistically significant(P<0.05).(3)Comparison of pruritus degree between two groups before and after treatment①By paired test,the difference of VAS score of the treatment group before and after treatment were statistically significant(P<0.05).②By paired test,the difference of VAS score of the control group before and after treatment were statistically significant(P<0.05).(4)Comparison of pruritus degree between two groups after treatment①By Independent sample test,The difference of VAS score after treatment between the two groups was statistically significant(P<0.05).②By Independent sample test,the difference of score variances of VAS score between the two groups before and after treatment was statistically significant(P<0.05).4.Efficiency comparison:①EASI data:After treatment,in the treatment group,The total clinical effective rate was 96.67%.In the control group,The total clinical effective rate was 83.33%.②VAS data:After treatment,in the treatment group,the total clinical effective rate was 100%.In the control group,The total clinical effective rate was 86.67%.By rank sum test,the clinical total effective rate of the two groups was compared,and there were significant differences between the two groups(P<0.05).Conclusion1.Both the treatment of filiform-fire needle combined with moxibustion and conventional western medicine can effectively improve the lesion area,severity and pruritus of patients with chronic eczema.2.The combination of filiform fire acupuncture and moxibustion is effective in improving the lesion area,skin erythema,papule,scale and lichenification with chronic eczema,and is superior to conventional western medicine treatment.3.The combination of filiform fire needle and moxibustion is better than conventional western medicine in improving the severity of pruritus in patients with chronic eczema.4.Filiform-fire needle combined with moxibustion is an effective,simple and easy physical therapy with few side effects,and there is no obvious adverse reaction in the treatment process,which is worthy of clinical promotion... |
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