Clinical Study On Modified Shensu Decoction In The Treatment Of Cough Variant Asthma(Syndrome Of Wind Evil Invading Lung And Syndrome Of Deficiency Of Lung Qi)

Objective: To observe the clinical efficacy of Modified Shensu Decoction with Budesonide and Formoterol Fumarate Powder for Inhalation on patients with cough variant asthma(syndrome of wind evil invading lung and syndrome of deficiency of lung qi),and to confirm the feasibility of Modified Shensu Decoction in the treatment of cough variant asthma(CVA),so as to provides a new Chinese medicine and western medicine treatment method for CVA.Methods: In this study,80 patients who were clearly diagnosed as CVA with syndrome of wind evil invading lung and syndrome of deficiency of lung qi were divided into treatment group and control group by random number table method,with 40 cases in each group.The control group was treated with Budesonide and Formoterol Fumarate Powder for Inhalation,and the treatment group was taken orally with Modified Shensu Decoction on the basis of the control group.The treatment course of the two groups was 4 weeks.After 4 weeks,the patients’ cough symptom score,TCM syndrome score,The Leicester Cough Questionnaire score,eosinophil count,and Pulmonary Function Testindexes(FEV1,FEV1/FVC)were compared.And verify the safety indicators such as blood routine indexes,liver function indexes and kidney function indexes,in order to evaluate the clinical efficacy of Modified Shensu Decoction with Budesonide and Formoterol Fumarate Powder for Inhalation.Result:1.Comparison of cough symptom scores:There was no statistically significant difference in total scores between the treatment group and the control group before treatment(P>0.05),and they were comparable.After 4 weeks of treatment,the total cough score of the two groups was significantly lower than that before the treatment(P < 0.05),but the decrease in the treatment group was more significant than that of the control group(P<0.05).2.Comparison of TCM syndrome scores: Before treatment,data analysis of the total scores of TCM syndromes of the treatment group and the control group found that there was no statistical significance(P > 0.05),and they were comparable.After 4 weeks of treatment,the total scores of the two groups were lower than before treatment(P < 0.05),which was statistically significant.And the total score of the treatment group was more significant than that of the control group(P<0.05).3.Comparison of The Leicester Cough Questionnaire(LCQ)scores: Before treatment,the LCQ scores of the treatment group and the control group were statistically analyzed.The total LCQ points,LCQ physiological area points,LCQ mental area points and LCQ social area points of the treatment group and the control group were not statistically significant(P >0.05),and they were comparable.After 4 weeks of treatment,the four points of the two groups were all higher than before treatment(P<0.05).And the increase in the treatment group was more significant than that in the control group(P<0.05).4.Comparison of eosinophil count:Before treatment,the eosinophil counts of the treatment group and the control group were not statistically significant(P > 0.05),and they were comparable.After 4 weeks of treatment,the eosinophil counts of the treatment group and the control group were lower than before treatment(P < 0.05),and the value of the treatment group dropped more significantly(P<0.05).5.Comparison of Pulmonary Function Test indexes: Before treatment,the FVE1 and FVE1/FVC values of the treatment group and the control group were not statistically significant(P > 0.05),and they were comparable.After 4 weeks of treatment,the FVE1 and FVE1/FVC values of the treatment group and the control group increased compared to before treatment(P<0.05).And the increase in the treatment group was more significant than that in the control group(P<0.05).6.Comparison of curative effect of traditional Chinese medicine symptoms: After 4 weeks of treatment,in the treatment group,5 cases achieved clinical control,11 cases were markedly effective,21 cases were effective,and 2 cases were ineffective.The total effective rate is 94.87%.In the control group,2 cases achieved clinical control,5 cases weremarkedly effective,23 cases were effective,and 7 cases were ineffective.The total effective rate was 81.08%.The data of the two groups showed that the treatment was effective.After further analysis of the total effective rate of the two groups,it was found that P<0.05,indicating that the curative effect of the treatment group was significantly better than that of the control group.7.Safety observation: During the 4-week treatment,no patients had obvious abnormalities in laboratory tests such as vital signs,blood routine,urine routine,stool routine,liver function,and kidney function.It shows that modified Shensu Decoction with Budesonide and Formoterol Fumarate Powder for Inhalation has high safety in the treatment of cough variant asthma(syndrome of wind evil invading lung and syndrome of deficiency of lung qi).Conclusion: Modified Shensu Decoction with Budesonide and Formoterol Fumarate Powder for Inhalation has a good effect on cough variant asthma(syndrome of wind evil invading lung and syndrome of deficiency of lung qi).Modified Shensu Decoction can effectively alleviate patients’ symptoms,improve Pulmonary Function Test indexes,and reduce inflammation indicators.It can be used as an effective prescription for treating cough variant asthma(syndrome of wind evil invading lung and syndrome of deficiency of lung qie).No obvious adverse reactions occurred during the treatment,and no toxic side effects.