| Objective: to observe the efficacy and safety of oral jiawei sangju decoction in the treatment of wind-heat attack lung syndrome of children’s cough variant asthma,and to provide clinical basis for the treatment of this disease with traditional Chinese medicine.Methods:According to western medicine diagnostic criteria for children cough variant asthma and sects heat attack in lung syndrome differentiation standard,selection in April 2019-December 2019 pediatric outpatient clinic first affiliated hospital of tianjin medical university of 60 cases,press the order of outpatient clinic of the serial number,according to the method of random Numbers are divided into the treatment group and control group 30 cases,the treatment group oral flavored sang ju Yin native Chinese medicine,the control group oral meng rust sodium chewable tablets,both set to 4 weeks for a period of treatment,respectively,to treat 1 week,2 weeks,3 weeks,4 weeks as a visit to view observation records with the change of main symptoms and secondary syndrome,Spss26.0 statistical software was used to analyze the data and draw a conclusion.Results :(1)After 4 weeks of treatment,the comparison of the total score of TCM syndromes,the main score and the secondary score in the two groups before and after treatment was statistically significant(P<0.05),indicating that the treatment group and the control group were effective in treating CVA.(2)The total effective rate of the treatment group and the control group was 96.55% and 89.29%,respectively,with no statistically significant difference(P>0.05).(3)The treatment group and control group total score in treatment of syndromes,there was no statistically significant difference after 1 week after treatment for 2 weeks,3 weeks after treatment,4 weeks after treatment the treatment group total score lower than the control group of syndromes,the treatment group after treatment for 2 weeks,3 weeks after treatment,4 weeks after treatment,the improvement of TCM syndrome is better than the control group.(4)Both the treatment group and the control group showed improvement at the end of treatment,and the improvement degree of the treatment group was better than that of the control group.Moreover,the improvement of the main disease in the treatment group was shown in the first week,while the improvement of the control group was shown in the second week,indicating that the improvement of the main disease in the treatment group was more rapid than that in the control group.(5)Comparison of the treatment group before and after treatment showed that after 1 week,2 weeks,3 weeks and 4 weeks,the total score of secondary symptoms was improved,and the symptoms of sore throat,dry mouth and thirst,chest tightness,nasal itching,sneezing,runny nose,nasal congestion,dry stool,and restless sleep were all improved.Comparison of the control group before and after treatment showed no improvement in the total score of secondary symptoms after 1 week of treatment,and some improvement in the total score of secondary symptoms after 2,3 and 4 weeks of treatment,but no significant improvement in mouth thirst,chest tightness,nasal congestion,and dry stools,and some improvement in sore throat,nasal itching,sneezing,runny nose,and restless sleep.The comparison between the two groups showed that the total score of the treatment group and the control group had no statistical significance after 1 week of treatment,and the total score of the treatment group was lower than that of the control group after 2 weeks of treatment,3 weeks of treatment and 4 weeks of treatment.After treatment,the scores of pharyngeal pain,nasal itch,runny nose,dry stool and restless sleep in the treatment group were lower than those in the control group.There was no significant difference in mouth thirst,chest tightness,sneezing and nasal congestion.The above conclusions indicated that both the treatment group and the control group could reduce the total score of secondary symptom,and the total score of secondary symptom improvement in the treatment group was better than that in the control group,and the improvement occurred earlier than that in the control group.The improvement of pharyngeal pain,nasal itching,runny nose,dry stools and restless sleep in the treatment group was better than that in the control group.(6)FEV1,FEV1/FVC,PEF,FEF50 and FEF75 all improved in pulmonary ventilation function before and after treatment.In the control group,PEF,FEV1 and FEV1/FVC were improved before and after treatment,while FEF50 and FEF7 were not significantly improved.After treatment,the improvement of PEF,FEF50 and FEF75 in the treatment group was better than that in the control group,and the improvement of FEV1 and FEV1/FVC showed no significant difference.The above results indicated that the improvement of lung function in the treatment group was better than that in the control group.(7)There was no statistically significant difference in the percentage of eosinophil in the treatment group and the control group before and after treatment,indicating that the percentage of eosinophil in the treatment group and the control group did not change significantly before and after treatment.(8)The number and frequency of boricone atomization inhalation in the treatment group were less than those in the control group,indicating that the condition of the treatment group was better than that of the control group;(9)Safety comparison between the two groups: no obvious adverse reactions or adverse events occurred in the two groups.Conclusion: oral jiawei sangju decoction and oral monrostrant sodium chewable tablets are effective in the treatment of infantile cough variant wheezing heat attacking lung syndrome.Oral modified sangju decoction is better than oral monrostrant sodium masticatory tablets in improving TCM syndrome,improving lung function and reducing the use of terbutaline sulfate in children.Moreover,no obvious adverse reactions were found in the treatment of wind and heat in children with cough variant asthma with oral jiawei sangju decoction. |
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