Clinical Study Of Qingre Huashi Tongmai Formula In The Treatment Of Early And Middle Knee Osteoarthritis Of Damp-heat Obstruction

Objective: In order to provide theoretical basis for clinical treatment of knee osteoarthritis of this syndrome,the clinical efficacy and safety of Qingre Huashi Tongmai prescription in relieving pain,improving joint function and TCM symptoms were observed by oral administration of Qingre Huashi Tongmai recipe in the early and middle stage of knee osteoarthritis of damp-heat obstruction type.Methods: This study collected patients who were outpatients in Donggeyuan District and Xianghuyuan District of the first affiliated Hospital of Guangxi University of traditional Chinese Medicine from April 2020 to January 2021.Sixty patients with early and middle knee osteoarthritis who met the inclusion criteria were randomly divided into treatment group(n = 30)and control group(n = 30).The control group was given celecoxib capsule oral combined with basic treatment(health education and exercise training),and the treatment group was given Qingre Huashi Tongmai recipe and the same basic treatment as the control group.The course of treatment in both groups was 2weeks.The VAS pain score,knee joint WOMAC score and TCM syndrome score of the two groups were recorded before and 2 weeks after treatment,and then the curative effects of the two groups were comprehensively evaluated and analyzed.SPSS26.0 statistical software was used for data processing and analysis,t-test was used for measurement data in accordance with normal distribution(rank sum test was used for variance discrepancy or non-normal distribution),independent sample t-test was used for inter-group comparison,paired sample t-test was used for intra-group comparison,chi-square test was used for counting data,and rank sum test was used for grade data(such as overall curative effect).The difference was statistically significant(P < 0.05),and the difference was significant(P < 0.01).Results:1.The 60 subjects included in this study did not fall off in the course of the trial,and all of them were included in the analysis of the results.The basic data(sex,age,location and course of disease),VAS score,knee joint WOMAC score and TCM syndrome score before treatment were analyzed and compared between the two groups(P > 0.05).There was no significant difference between the two groups.2.VAS score: After treatment,the VAS scores of the two groups were lower than those before treatment,and there was significant difference between the two groups(P < 0.01),indicating that the treatment methods of the two groups were effective in relieving pain.After 2 weeks of treatment,there was no significant difference between the two groups(P > 0.05).It shows that the two groups of treatments have the same effect in relieving pain.3.WOMAC score: After treatment,the pain,morning stiffness and daily activities of the two groups were significantly improved compared with those before treatment,and the total score of WOMAC was lower than that before treatment(P < 0.01).After 2 weeks of treatment,there was no significant difference in pain relief between the two groups(P > 0.05),but there was significant difference in morning stiffness and improvement of daily activities(P < 0.05).It shows that the treatment methods of the two groups have obvious curative effect in relieving knee joint pain,improving joint stiffness and functional activity.the treatment group is similar to the control group in relieving joint pain,and is better than the control group in improving joint stiffness and functional activity.4.TCM syndrome score: After treatment,the TCM symptom scores of the two groups were lower than those before treatment,and the difference was statistically significant(P < 0.01).After 2 weeks of treatment,there was significant difference between the two groups(P < 0.05).It shows that the treatment methods of the two groups can improve the clinical symptoms of TCM,and the improvement of TCM symptoms in the treatment group is better than that in the control group.5.The results of clinical efficacy analysis of the disease: the total effective rate of the treatment group was 93.33%,while that of the control group was 76.67%.By rank sum test,there was significant difference in the total effective rate between the two groups after treatment(P < 0.05).The clinical effect of the treatment group was better than that of the control group.6.The result of TCM syndrome curative effect analysis: the total effective rate of the treatment group was 96.67%,and that of the control group was 76.67%.By rank sum test,there was significant difference between the two groups(P < 0.05).Conclusion:1.For patients with early and middle knee osteoarthritis of damp-heat obstruction type,Qingre Huashi Tongmai prescription is accurate and appropriate,and has achieved satisfactory clinical curative effect,which is an effective treatment scheme for this syndrome type of knee osteoarthritis.2.Qingre Huashi Tongmai recipe in the treatment of early and middle knee osteoarthritis patients with damp-heat obstruction can effectively improve knee joint activity function,reduce joint pain,improve patients’ quality of life,and has a definite clinical effect,which is worthy of clinical application.3.In the course of this study,there were no obvious adverse reactions and no drug-related side effects,indicating that the group of drugs are safe and effective,and there are no obvious side effects.