Clinical Observation Of Bushen Qingre Huoxue Prescription In Treating Of Ankylosing Spondylitis(Damp-Heat Obstruction Syndrome)

ObjectiveTo explore the efficacy and safety of Bushen Qingre Huoxue Prescription combined with western medicine in the treatment of AS Damp-heat Obstruction Syndrome,a case-control study was conducted between the experimental group(Bushen Qingre Huoxue Prescription+Sulfasalazine+Diclofenac sodium)and the control group(Sulfasalazine+Diclofenac sodium).This study provides a theoretical basis for the treatment of AS Damp-heat Obstruction Syndrome.MethodPatients were selected from the outpatient department of Orthopaedics and rheumatism in the Second Affiliated Hospital of Henan University of Tradi tional Chinese Medicine were randomly divided into experimental group and control group with 30 cases in each group.The control group was given Sulfasalazine + Diclofenac sodium,and the experimental group was given Bushen Qingre Huoxue Prescription on this basis.The two groups were observed for 12 weeks.The safety indexes were checked at 0,4,8 and 12 weeks.The changes of Schober test,finger-to-ground distance,occipital-wall distance,ESR,CRP,PGA,BASDAI,BASFI,VAS score of spinal pain and TCM symptom scores were observed before and after treatment.Result(1)The total effective rates of TCM syndromes in the experimental group and the control group were 89.66% and 63.33%,respectively,with statistical significance(P < 0.05).There was a significant difference in TCM syndrome scores in the intra-group and inter-group comparisons(P < 0.05).The results showed that after treatment,the TCM syndrome scores of the two groups were improved,and the experimental group was better than the control group.(2)After treatment,the compliance rate of ASAS20 in the experimental group was 89.7%,which was significantly higher than that in the control group(63.3%),and the difference was statistically significant(P<0.05).There were significant differences in the scores of PGA,BASDAI,BASFI and VAS score of spinal pain in the intra-group and inter-group comparisons(P < 0.05).The scores of PGA,BASDAI,BASFI and nocturnal back pain VAS of the experimental group and the control gro up were significantly lower than those of the former,showing that the therapeutic effect of the experimental group was better than that of the control group.(3)The clinical measurement indexes(Schober test,finger-to-ground distance,occipital-wall distance)in the intra-group and inter-group comparisons showed significant differences(P < 0.05),indicating that the clinical measurement indexes of the two groups were improved,and the experimental group was better than the control group.(4)The difference of laboratory indexes(ESR,CRP)in the intra-group and inter-group comparisons was statistically significant(P < 0.05).The results showed that the laboratory indexes of the two groups decreased after treatment,and the experimental group was better than the control group.(5)Safety analysis showed that there were 1 case of adverse reactions in the experimental group and 5 cases in the control group during the treatment period.There was no significant difference in the occurrence of adverse reactions be tween the two groups(P > 0.05).ConclusionTraditional Chinese medicine Bushen Qingre Huoxue Prescription combined with western medicine has better therapeutic effect than western medicine alone in treating Damp-heat Obstruction Syndrome of ankylosing spondylitis.It can improve laboratory index(ESR,CRP),clinical measurement index(Schober test,finger-to-ground distance,occipital-wall distance),PGA,BASDAI,BASFI,VAS score of spinal pain and TCM syndrome scores.