| Objective: This subject research is based on quadriceps exercise.The Huayu Qushi Recipe on the changes of symptoms,signs and serum factors in patients with knee osteoarthritis(KOA)before and after treatment is compared with the western medicine of the control group for further evaluation.The mechanism of action,effectiveness and safety of Huayu Qushi Decoction in the treatment of phlegm-dampness-stasis KOA are intended to provide further reference and clinical evidence for the clinical application of traditional Chinese medicine(the method of removing blood stasis and dispelling dampness)in the treatment of KOA patients.Methods: According to the random number table method,40 patients with KOA of phlegm-dampness stasis type were randomly divided into treatment group and control group,with 20 cases in each group.The treatment group was given the method of removing blood stasis and dampness combined with quadriceps femoris exercise,and the control group was given meloxicam granules combined with quadriceps femoris exercise.The treatment course was 2 weeks.After the treatment,the observation was continued for 2 weeks(that is,the observation was included for 4 weeks).Observe the treatment of VAS score,Lysholm score,TCM symptom score,overall efficacy comparison,and serum PGE2,MMP-13 level comparison.All collected data will be processed by SPSS20.0 statistical software.Results: A total of 1 case was dropped,and finally 39 cases participated in the statistics,20 cases in the treatment group and 19 cases in the control group.1.Comparison of VAS scores: The scores of the two groups were significantly reduced after 2 weeks of medication(P<0.01),and the scores of the control group showed a tendency to rise 2 weeks after drug withdrawal,which was different from that of 2 weeks of medication(P<0.01)),2 weeks after stopping the treatment,there was no obvious trend of recovery in the score of the treatment group,and there was no significant difference compared with the 2 weeks of treatment(P>0.05).The curative effect of the two groups was equivalent at 2 weeks of medication(P>0.05),and the scores of the two groups were different(P<0.01)2 weeks after stopping the medication,and the treatment group was lower than the control group.2.Comparison of Lysholm scores: the scores of the two groups were significantly increased after 2 weeks of medication(P<0.01),and the scores of the control group showed a downward trend at 2 weeks after stopping the medication,which was different from that of 2 weeks of medication(P<0.05)),the score of the treatment group did not show a significant decline in the 2 weeks after the drug was stopped,and there was no significant difference compared with the 2 weeks of the drug(P>0.05).The curative effect of the two groups was equivalent at 2 weeks of medication(P>0.05),and the scores of the two groups were different(P<0.05)2 weeks after stopping the medication,and the treatment group was higher than the control group.3.Comparison of the scores of various symptoms of KOA: The two groups had a definite effect on swelling and activity limitation after 2weeks of medication(P<0.01).The two groups had better swelling and activity limitation 2 weeks after stopping the drug.The change was obvious after 2 weeks of medication(P<0.01).The curative effect of the two groups was similar when the medication was used for 2 weeks on swelling and restricted activity,and 2 weeks after stopping the medication(P>0.05).Tenderness and tingling were effective after 2 weeks of medication(P<0.01).The treatment group changed significantly after 2weeks of drug withdrawal(P<0.01),while the control group had no significant improvement(P>0.05)).The curative effect was equivalent to the treatment of tenderness and tingling for 2 weeks(P>0.05),and the treatment group was better than the control group 2 weeks after stopping the drug(P<0.05).In terms of lower extremity focus,the treatment group was significantly different from the treatment group at 2 weeks before treatment,and at 2 weeks after stopping the medicine compared with the treatment at 2 weeks(P<0.01),and it was better than the control group at2 weeks(P<0.05).Two weeks after the treatment,it was significantly better than the control group(P<0.01).In the control group,there was no significant improvement in the severe symptoms of lower extremities no matter when the drug was used for two weeks or two weeks after the drug was stopped(P>0.05).4.Comparison of the total scores of various symptoms of KOA: The total scores of symptoms of the two groups changed significantly after 2weeks of medication and before treatment,2 weeks after drug withdrawal and 2 weeks of medication(P<0.01).At 2 weeks of medication,the treatment group and the control group had the same curative effect on the total score(P>0.05),but the curative effect of the treatment group was better than the control group(P<0.01)2 weeks after the drug was stopped.5.Comparison of overall efficacy: the effective rate of the treatment group was 95.0%;the effective rate of the control group was 84.2%.The overall effective rate of the treatment group was better than that of the control group(P<0.05).6.Comparison of PGE2 levels: There were significant differences between the two groups at 2 weeks and before treatment(P<0.01),and the difference between the treatment group at 2 weeks and 2 weeks after drug withdrawal was significant(P <0.01),while the difference in the control group was not Obviously(P>0.05).The effect of the two groups was equivalent at 2 weeks of medication(P>0.05),and the treatment group was lower than the control group(P<0.05)2 weeks after stopping the medication.7.Comparison of MMP-13 levels: the two groups were significantly different between the two groups after treatment for 2 weeks and before treatment(P<0.01),and the difference between the treatment group and the treatment group was significant(P<0.01)2 weeks after the drug was stopped and the treatment group for 2 weeks.The difference is not obvious(P>0.05).The effect of the two groups was equivalent at 2 weeks of medication(P>0.05),and the treatment group was lower than the control group(P<0.05)2 weeks after stopping the medication.8.Safety indicators: The safety indicators of the two groups of patients were within the normal range,and no adverse reactions were found during medication.conclusion:1.The intervention mechanism of Huayu Qushi Recipe in treating phlegm-dampness and stasis KOA is related to the reduction of PGE2 and MMP-13 levels.2.Huayu Qushi Recipe can well relieve the symptoms and signs of KOA patients with phlegm-dampness stasis syndrome,change the physique of the disease,and it is not easy to relapse after stopping the drug,and it is clinically worth promoting. |
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