Study Of Correlation Between Distribution Of TCM Syndrome Types Of Post-Stroke Depression And Constitution And Influencing Factors

Objective:To study the distribution of TCM syndrome types of post-stroke depression(PSD)and TCM constitution,explore the relationship between syndrome types and constitution and other related factors,in order to improve the accuracy of PSD syndrome types.Provide objective basis for the prevention and medication of PSD.Methods:166 patients were selected from the Department of Brain Diseases of Nanjing Hospital of TCM who met the criteria.We first collect the patient’s general information and four-diagnosis information,and then use the four-diagnosis information to determine the TCM syndrome types and TCM constitution.The HAMD,NIHSS,BI,and MoCA were used to evaluate depression degree,neurological deficit degree,daily living ability level,and cognitive function of the patients.Use SPSS26.0 software to perform statistical tests on the data to analyze the correlation between syndrome types and constitution and other factors.Results:1.In this study,the most common TCM syndrome types was liver Qi stagnation and spleen deficiency,followed by heart and spleen deficiency,kidney deficiency and liver Qi stagnation,heart and kidney discord,liver and gut damp heat,and heart and gut Qi deficiency.The most common constitution was Qi depression,followed by Qi deficiency,phlegm dampness,blood stasis,Yang deficiency,damp heat,Yin deficiency and gentle constitution.After statistical testing,there are significant differences in the constitutional distribution of different syndrome types(P<0.05).There is a correlation between constitution and syndrome types.People with Yin deficiency tend to develop into heart and kidney discord.Those with Qi deficiency tend to develop into heart and spleen deficiency,rather than kidney deficiency and liver Qi stagnation.Those with blood stasis tend to develop into kidney deficiency and liver Qi stagnation.Those with phlegm dampness tend to develop into liver Qi stagnation and spleen deficiency.Those with Yang deficiency tend to develop into heart and spleen deficiency.2.There are differences in the distribution of gender,age,course of disease,depression degree,neurological deficit degree,and daily living ability level of PSD patients with different TCM syndrome types,and the differences have been verified to be statistically significant.Single factor analysis:Gender:Female patients with PSD tend to develop into liver Qi stagnation and spleen deficiency,male patients with PSD tend to develop into heart and spleen deficiency(P<0.05).Age:Elderly patients with PSD tend to develop into kidney deficiency and liver Qi stagnation(P<0.05).Course of disease:PSD patients in the acute phase of stroke tend to develop into liver Qi stagnation and spleen deficiency rather than kidney deficiency and liver Qi stagnation.PSD patients in the sequelae of stroke tend to develop into kidney deficiency and liver Qi stagnation rather than liver Qi stagnation and spleen deficiency(P<0.05).Depression degree:The HAMD score of PSD patients with kidney deficiency and liver Qi stagnation was significantly higher than that of PSD patients with liver Qi stagnation and spleen deficiency and liver and gut damp heat(P<0.05).Neurological deficit degree:The NIHSS score of PSD patients with kidney deficiency and liver Qi stagnation and heart and spleen deficiency was significantly higher than that of PSD patients with liver Qi stagnation and spleen deficiency(P<0.05).Daily living ability level:BI score of PSD patients with kidney deficiency and liver Qi stagnation and heart and spleen deficiency was significantly lower than that of PSD patients with liver Qi stagnation and spleen deficiency(P<0.05).There was no statistically significant difference in the cognitive function of different syndrome types(P>0.05).3.The binary logistic stepwise regression analysis of the main syndrome types shows that the factors related to liver Qi stagnation and spleen deficiency syndrome are NIHSS score,female,within 2 weeks of the disease course,and phlegm dampness.The factors related to heart and spleen deficiency syndrome are male,Qi deficiency,Yang deficiency.The factors related to kidney deficiency and liver Qi stagnation syndrome are age greater than 59 years old,over 6 months of the disease course and blood stasis.Conclusion:1.The TCM syndrome types of PSD patients are mainly liver Qi stagnation and spleen deficiency,heart and spleen deficiency,kidney deficiency and liver Qi stagnation.2.The distribution of constitution in different TCM syndrome types of PSD patients is different.Among them,Yin deficiency and heart and kidney discord,Qi deficiency and heart and spleen deficiency,blood stasis and kidney deficiency and liver Qi stagnation,phlegm dampness and liver Qi stagnation and spleen deficiency,and Yang deficiency and heart and spleen deficiency are all significant correlation.3.The TCM syndrome types of PSD patients is correlated with gender,age,course of disease,depression degree,neurological deficit degree and daily living ability level,but has no obvious correlation with cognitive function.