Effect Of Modified Sijunzi Tang In The Treatment Of Deficiency Of Splenic Qi Type Of Postoperative Fatigue Syndrome In Patients After Laparoscopic Cholecystectomy

ObjectiveThe study in order to observe the effectiveness and safety of Sijunzi Decoction of deficiency of splenic qi type of postoperative fatigue syndrome after laparoscopic cholecystectomy by of randomized controlled trial,to explore the mechanism of the treatment of postoperative fatigue syndrome(PFS)after laparoscopic cholecystectoLC(lc),and to provide reference for clinical treatment.MethodsFrom August 2020 to December 2020,datas of 38 patients who have postoperative fatigue syndrome after laparoscopic cholecystectomygallbladder and were regarded as deficiency of spleen-qi syndrome were collected in the General Surgery Department of Jiangsu Provincial Hospital of traditional Chinese medicine in this research.The patients were divided into two groups at random:control group and treatment group.Conventional therapy were taken by the control group.The treatment group was treated with routine treatment and jiawei sijunzi decoction(10g Codonopsis pilosula,10g Atractylodes rhizome,10g Poria,3g Roasted licorice,10g Radix astragali stir-fried,10g Pinellia ternata,6g Dried tangerine peel,10g Chinese yam,6g Radix bupleuri and 6g Prunella vulgaris)from first day post-op,4:00 p.m.for14 days.The scores of preoperative and Postoperative Day 1 and postoperative day 14 were measured by Christensen scale,ICFS Scale and symptoms scale,the serum levels of total bilirubin(TBIL),serum transferrin(TRF),serum prealbumin(PA)and Hypersensitive C reaction(HS-CRP)were measured before operation,postoperative Day 1 and postoperative day 14.Data collection and collation using Excel software,statistics and analysis using SPSS 23.0 software.Results(1)In this study,there was no statistical difference between the two groups(P>0.05)in the scores of Christensen’s Fatigue Score and ICFS scale preoperatively and on the first day postoperatively,all the patients had fatigue after laparoscopic cholecystectomy,and the degree of fatigue decreased gradually with the development of time.On the 14th day after the operation,the scores of Christensen and ICFS in the treatment group were lower than those in the control group.The results showed that jiawei sijunzi decoction was beneficial to relieve the postoperative fatigue of patients with spleen-qi deficiency type after laparoscopic cholecystectomy.(2)There was no statistical difference in the levels of serum Tbil,serum TRF,serum PA and CRP between the two groups before operation and the first day after operation(P>0.05);In the two groups,the levels of serum Tbil and CRP)were more,while the levels of serum TRF and serum PA were lower on the first day after operation than those before operation(P<0.05).The results showed that the nutritional status decreased and inflammatory factors increased after operation.The serum levels of Tbil and PA in the treatment group were significantly improved than those in the control group on the 14th day after operation(P<0.05),it is suggested that jiawei Sijunzi decoction has significance in improving postoperative nutritional status and reducing serum total bilirubin.(3)On the 14th day after operation,TRF and CRP of the two groups improved significantly compared with the 1st day after operation(P<0.05),and there was no statistical difference between the two groups on the 14th day after operation(P>0.05),it is suggested that the effect of Jiawei Sijunzi decoction on increasing TRF level and decreasing CRP is unclear.(4)There was no statistical difference(P>0.05)between the two groups on the first day after operation,but there was statistical difference(P<0.05)between the two groups on the 14th day after operation,it indicates that jiawei sijunzi decoction has certain effect on treating postoperative fatigue of LC with deficiency of spleen-qi.ConclusionAfter laparoscopic cholecystectomy,fatigue symptoms were found in different degrees.Christensen scale,ICFS scale,serum total bilirubin and prealbumin were measured to suggest that jiawei sijun zi decoction has some effect on relieving postoperative fatigue and improving postoperative nutritional status of patients with laparoscopic cholecystectomy,but has no obvious evidences on serum TRF and CRP.Jiawei Sijunzi decoction can ameliorate the postoperative fatigue syndrome of patients with spleen-qi deficiency after laparoscopic cholecystectomy.Based on this research,the theory of clinical treatment of postoperative fatigue syndrome were enriched.At the same time,the number of options available to patients has increased.